1. Chemistry and Biology of Retinoids
2. Stereocontrolled Synthesis of Carotenoids and Related Polyenes
3. Design and Synthesis of Epigenetic Modulators Based on Natural Products
4. Computational Analysis of Pericyclic and Other Concerted Reactions
5. Computational Analysis of Organometallic Catalytic Processes
a) Retinal and retinoid metabolism;
b) Vision in vertebrates;
c) Bacterial photopigments;
d) Nuclear receptor biology through the design and synthesis of selective modulators . Convergent approaches to both the side-chain and the rings of complex carotenoids decorated with functional groups and stereocenters including allene axis. Development of novel epigenetic drugs targeting HDACs, HATs, PRMTs and DNMTs using two structure-based general approaches to drug design and development:
a) virtual ligand screening (VLS) of large libraries of drug-like molecules following modeling of the receptor-ligand interaction complexes and selection of leads;
b) focused-library development of libraries based on VS or in privileged structures inspired in natural products already reported as epigenetic modulators. Characterization of pericyclic and pseudopericyclic electrocyclic ring closure reactions, in particular of charged species (carbocations, carbanions) and the mechanism of the chirality transfer.
The Pd-catalyzed and Zn-promoted intramolecular propargylation of carbonyl compounds.