Publications

2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000

 
(TOP)   2017


11.-On the regiochemical differences between Pd-catalyzed heterocyclization–allylation and –arylation reactions of alkynylbenzamides: preparation of 4-allyl-isochromen-1-imines and computational study
Rosana Álvarez, Unai Vilar, Youssef Madich and José M. Aurrecoechea.
Org. Biomol. Chem., 2017,15 (40), 8594-8605

10.-Mass Spectrometry of Algal Chlorophyll c Compounds
Antonio Gavalás-Olea, José Luis Garrido, Pilar Riobó, Susana Álvarez and Belen Vaz.
Current Organic Chemistry., 2017, (sep, 2017, ahead of print)

9.-Indole–Indole Ullmann Cross-Coupling for CAr–N Bond Formation: Total Synthesis of (–)-Aspergilazine A
Iago Alonso, Rosana Alvarez and Angel R. de Lera
Eur. J. Org. Chem. 2017, 4948–4954 (sep 6, 2017)

8.-Synthesis of the octahydronaphthalene core of nahuoic acid A via a B(C6F5)3-catalyzed intramolecular Diels–Alder (IMDA) reaction
Lucía Guillade, Adán B. González-Pérez and Ángel R. de Lera
Org. Biomol. Chem., 2017,15, 7430–7438 (Aug 17, 2017)

7.-Speciation of ZnMe2, ZnMeCl, and ZnCl2 in Tetrahydrofuran (THF), and Its Influence on Mechanism Calculations of Catalytic Processes
Juan del Pozo, María Pérez-Iglesias, Rosana Álvarez, Agustí Lledós, Juan A. Casares, and Pablo Espinet
ACS Catal., 2017, 7, pp 3575–3583 (April 11, 2017)

6.-Natural and structure-based RXR ligand scaffolds and their functions.
Marta Domínguez, Susana Alvarez, Angel R de Lera
Current Topics in Medicinal Chemistry, 2017-03-01, 17, 6, 631-662 (Review)

5.-Structural basis for the inhibition of AKR1B10 by the C3 brominated TTNPB derivative UVI2008.
Francesc X Ruiz, Isidro Crespo, Susana Álvarez, Sergio Porté, Joan Giménez-Dejoz, Alexandra Cousido-Siah, André Mitschler, Ángel R de Lera, Xavier Parés, Alberto Podjarny, Jaume Farrés
Chemico-Biological Interactions, 2017-02-01, 17, 1, 24pages

4.-Lineage-specific duplication of amphioxus retinoic acid degrading enzymes (CYP26) resulted in sub-functionalization of patterning and homeostatic roles.
João E Carvalho, Maria Theodosiou, Jie Chen, Pascale Chevret, Susana Alvarez, Angel R De Lera, Vincent Laudet, Jenifer C Croce, Michael Schubert
BMC Evolutionary Biology, 2017-01-19, 17:24 pages

3.-Rearrangement of vinyl allene oxide geometric isomers to cyclopentenones. Further computational insights with biologically relevant model systems.
Adán B. González-Pérez, Alexander Grechkinb and Ángel R. de Lera
Org. Biomol. Chem., 2017, 15, 2846, march

2.-Reduced adiponectin expression after high-fat diet is associated with selective up-regulation of ALDH1A1 and further retinoic acid receptor signaling in adipose tissue
Landrier J.F., Kasiri E., Karkeni E., Mihaly J., Beke G., Weiss K., Aydemir G., Salles J., Walrand S., de Lera A.R., Rühl R.
The FASEB Journal. January 2017, vol. 31 no. 1 203-211,

1.-Total synthesis of naturally occurring (+)-psychotriasine and the related tetrahydro-β-carboline, dimeric tryptamines with N–C connectivities.
Samuel Gallego, Paula Lorenzo, Rosana Álvarez and Ángel R. de Lera
Tetrahedron Letters. Volume 58, Issue 3, 18 January 2017, Pages 210–212

 
(TOP)   2016


10.-Epigenetic polypharmacology: from combination therapy to multitargeted drugs.
A.R. de Lera; A. Ganesan.
Clinical Epigenetics. 8 - 1, 12/10/2016

9.-Relationship between All-trans-13,14-Dihydro Retinoic Acid and Pancreatic Adenocarcinoma.
A.V. Bazhin; T. Bleul; A.R. De Lera; J. Werner; R. Rühl.
Pancreas. 45 - 6, pp. e29 - e31. 12/10/2016

8.-An Endogenous Mammalian Retinoid X Receptor Ligand, at Last!
Á.R. De Lera; W. Krezel; R. Rühl
ChemMedChem. 11 - 10, pp. 1027 - 1037. 19/05/2016

7.-The Negishi Catalysis: Full Study of the Complications in the Transmetalation Step and Consequences for the Coupling Products
Juan del Pozo, Gorka Salas, Rosana Álvarez, Juan A. Casares, and Pablo Espinet
Organometallics, September 30, 2016

6.-19,19'-Diacyloxy Signature: An Atypical Level of Structural Evolution in Carotenoid Pigments
Antonio Gavalás-Olea, Susana Alvarez, Pilar Riobó, Francisco Rodríguez, José L. Garrido, and Belén Vaz
Org. Lett., 2016, 18 (18), pp 4642–4645; Sep 2016,

5.-Stereocontrolled synthesis of (S)-9-cis- and (S)-11-cis-13,14-dihydroretinoic acid
Belén Vaz, Rosana Alvarez, Angel R. de Lera
Tetrahedron, Volume 72, Issues 27–28, 7 July 2016, Pages 3898–3904

4.-Friedel–Crafts Alkylation of Indoles with p-Quinols: The Role of Hydrogen Bonding of Water for the Desymmetrization of the Cyclohexadienone System
Carolina García-García, Laura Ortiz-Rojano, Susana Alvarez, Rosana Alvarez, María Ribagorda,and M. Carmen Carreño
Org Lett, 2016, 18 (9), pp 2224–2227

3.-Evolutionary diversification of retinoic acid receptor (RAR) ligand-binding pocket structure by molecular tinkering
Juliana Gutierrez-Mazariegos, Eswar Kumar Nadendla, Romain A. Studer, Susana Alvarez, Angel R. de Lera, Shigehiro Kuraku, William Bourguet, Michael Schubert, Vincent Laudet
R. Soc. open sci., 2016, 3: 150484. 16 March 2016

2.-Exploiting the Multidentate Nature of Chiral Disulfonimides in a Multicomponent Reaction for the Asymmetric Synthesis of Pyrrolo[1,2-a]indoles: A Remarkable Case of Enantioinversion
Dr. Alicia Galván, Dr. Adán B. González-Pérez, Prof. Dr. Rosana Álvarez, Prof. Dr. Angel R. de Lera, Prof. Dr. Francisco J. Fañanás, and Prof. Félix Rodríguez.
Angewandte Chemie 2016, Volume 55, Issue 10, March 1 2016; Pages 3428–3432

1.-TSLP expression in the skin is mediated via RAR?-RXR pathways
Mihaly J., Gericke J., Lucas R., de Lera, A.R., Alvarez S., Törocsik D., Rühl R.
Immunobiology 2016, Vol 221, Issue 2, Feb2016, 161–165

 
(TOP)   2015


10.-Stereoselective [3+2]-Carbocyclization of Indole Derived Imines and Electron-Rich Alkenes: A Divergent Synthesis of Cyclopenta[b]indole or Tetrahydroquinoline Derivatives
Alicia Galván, Jonás Calleja, Adán B. González-Pérez, Rosana Álvarez, Angel R. de Lera, Francisco J. Fañanás and Félix Rodríguez
Chem. Eur. J. 2015, Nov 16;21(47):16769-74.

9.-Structural determinants of the selectivity of 3-benzyluracil-1-acetic acids towards human enzymes aldose reductase and AKR1B10
Ruiz, Francesc; Cousido-Siah, Alexandra; Porte, Sergio; Dominguez, Marta; Crespo, Isidro; Rechlin, Chris; Mitschler, Andre; de Lera, Angel; Martín, Maria; de la Fuente, Jesus; Klebe, Gerhard; Pares, Xavier; Farres, Jaume; Podjarny, Alberto
ChemMedChem, 2015, in print, 2015 Nov 9.

8.-Modulation of Retinoic Acid Receptor Subtypes by 5- and 8-Substituted (Naphthalen-2-yl)-based Arotinoids
Susana Alvarez, Michele Lieb, Claudio Martínez, Harshal Khanwalkar, Fátima Rodríguez-Barrios, Rosana Alvarez, Hinrich Gronemeyer, Angel R. de Lera
ChemMedChem 2015, 10, 1378-1391.

7.- 9-cis-13,14-dihydroretinoic acid is an endogenous retinoid acting as RXR ligand in mice
Ralph Rühl, Agnieszka Krzyzosiak, Anna Niewiadomska-Cimicka, Natacha Rochel, Lajos Szeles, Belen Vaz, Marta Wietrzych-Schindler, Susana Alvarez, Monika Szklenar, Laszlo Nagy, Angel R. de Lera, Wojciech Krezel
PLOS Genetics 2015, 11, e1005213.

6.-Evolution of the Role of RA and FGF Signals in the Control of Somitogenesis in Chordates
Stéphanie Bertrand, Daniel Aldea, Silvan Oulion, Angel R. de Lera, Marie-Line Escande, Ildiko Somorjai, Hector Escriva
PLOS ONE 2015; 10(9): e0136587

5.-Palladium-Catalyzed 6-endo-Selective Oxycyclization–Alkene Addition Cascades of ortho-Alkynylarylcarboxamides and alpha,beta-Unsaturated Carbonyl Compounds
Youssef Madich, Rosana Álvarez, and José M. Aurrecoechea
Eur. J. Org. Chem., 2015, Volume 2015, Issue 28, pages 6298–6305, Oct-2015.

4.-Organometallic Nucleophiles and Pd: What Makes ZnMe2 Different? Is Au Like Zn?
Juan delPozo, Estefanía Gioria, Juan A. Casares, Rosana Álvarez, and Pablo Espinet
Organometallics, 2015, 34 (13), pp 3120–3128.

3.-Synthesis of labile all-trans-7,8,7’,8’-bis-acetylenic carotenoids by bidirectional Horner-Wadsworth-Emmons condensation.
Belén Vaz, Noelia Fontán, Marta Castiñeira, Rosana Álvarez, and Ángel R. de Lera
Organic & Biomolecular Chemistry, 2015,13, 3024-3031.

2.-Synthesis of 7-Alkylidene-7,12-dihydroindolo[3,2-d]benzazepine-6-(5H)-ones (7-Alkylidene-Paullones) by N-cyclization-Oxidative Heck Cascade and Characterization as Sirtuin Modulators.
J. G. Denis, G. Franci, L. Altucci, J. M. Aurrecoechea, A. R. de Lera, and R. Álvarez
Organic & Biomolecular Chemistry, 2015, 13, 2800-2810.

1.-Palladium Nanoparticle-Loaded Cellulose Paper: A Highly Efficient, Robust, and Recyclable Self-Assembled Composite Catalytic System.
Guangchao Zheng, Katharina Kaefer, Stefanos Mourdikoudis, Lakshminarayana Polavarapu, Belén Vaz, Samantha E. Cartmell, Azzedine Bouleghlimat, Niklaas J. Buurma, Luis Yate, Ángel R. de Lera, Luis M. Liz-Marzán, Isabel Pastoriza-Santos, and Jorge Pérez-Juste
J. Phys. Chem. Lett., 2015, 6 (2), pp 230–238.

 
(TOP)   2014

10.-Roles of retinoic acid and Tbx1/10 in pharyngeal segmentation: amphioxus and the ancestral chordate condition
Demian Koop, Jie Chen, Maria Theodosiou, João E Carvalho, Susana Alvarez, Angel R de Lera, Linda Z Holland, and Michael Schubert
EvoDevo 2014, 5:36 (9 October 2014)

9.-Silicon particles as trojan horses for potential cancer therapy.
Roberto Fenollosa, Eduardo Garcia-Rico, Susana Alvarez, Rosana Alvarez, Xiang Yu, Isabel Rodriguez, Susana Carregal-Romero, Carlos Villanueva, Manuel Garcia-Algar, Pilar Rivera-Gil, Angel R de Lera, Wolfgang J Parak, Francisco Meseguer and Ramón A Alvarez-Puebla
Journal of Nanobiotechnology, 2014, 12:35, 10p.

8.-A unifying mechanism for the rearrangement of vinyl allene oxide geometric isomers to cyclopentenones.
Adán B. González-Pérez, Alexander Grechkin and Ángel R. de Lera
Org. Biomol. Chem., 21oct2014, 12 (39), 7694-7701

7.-Palladium-Catalyzed Regioselective 5-exo-O-Cyclization/Oxidative Heck Cascades from o-Alkynylbenzamides and Electron-Deficient Alkenes.
Youssef Madich, Rosana Álvarez and José M. Aurrecoechea.
Eur. J. Org. Chem. Volume 2014, Issue 28, 6263–6271, Oct-2014

6.-Dual RXR Agonists and RAR Antagonists Based on the Stilbene Retinoid Scafold.
Claudio Martínez, Michele Lieb, Susana Alvarez, Fátima Rodríguez-Barrios, Rosana Alvarez, Harshal Khanwalkar, Hinrich Gronemeyer, and Angel R. de Lera.
ACS Med. Chem. Lett. 2014, 5 (5), 533-537

5.-Total Synthesis and Structural Revision of (–)-Protubonine A and (–)-Protubonine B.
Paula Lorenzo, Rosana Alvarez, and Angel R. de Lera.
Eur. J. Org. Chem. Volume 2014, (12), pages 2557–2564

4.-Total Synthesis and Structural Revision of (+)-Cristatumin C.
Paula Lorenzo, Rosana Alvarez, and Angel R. de Lera.
J. Nat. Prod., 2014, 77 (2), pp 421–423

3.-Enantioselective Synthesis of Hexahydrofuro[3,2-c]quinolines through a Multicatalytic and Multicomponent Process. A New “Aromatic Sandwich” Model for BINOL-Phosphoric Acid Catalyzed Reactions.
Jonás Calleja, Adán B Gónzalez Pérez, Angel R. de Lera, Rosana Alvarez, Francisco Fañanas, and Félix Rodríguez.
Chem. Sci., 2014,5 (3), 996-1007

2.-Identification of a novel polyfluorinated compound as a lead to inhibit human enzymes aldose reductase and AKR1B10: structure determination of both ternary complexes and implications for drug design.
A. Cousido-Siah, F. X. Ruiz, A. Mitschler, S. Porté, Á. R. de Lera, M. J. Martín, S. Manzanaro, J. A. de la Fuente, F. Terwesten, M. Betz, G. Klebe, J. Farrés, X. Parés and A. Podjarny.
Acta Cryst. D. 2014, D70, 889-903

1.-Functions, Therapeutic Applications, and Synthesis of Retinoids and Carotenoids
Rosana Álvarez, Belén Vaz, Hinrich Gronemeyer and Ángel R. de Lera.
Chemical Reviews 2014; 114 (1), 1-125
  Special Issue: Chemistry and Biology of Retinoids and Carotenoids.

 
(TOP)   2013

13.-A Practical Protocol for Three-Component One-Pot Stepwise Sonogashira-Heterocyclization/Heck-Couplings
Youssef Madich, J. Gabriel Denis, Aitor Ortega, Claudio Martínez, Abdellatif Matrane, Majid Belachemi, Angel R. de Lera, Rosana Alvarez, José M. Aurrecoechea.
Synthesis 2013; 45(14), 2009-2017

12.-Catalyst- and Solvent-Dependent Stereodivergence in the Intramolecular Et2Zn/Pd0-Promoted Carbonyl Propargylation: Mechanistic Implications
Mónica Arrate, Aritz Durana, Paula Lorenzo, Ángel R. de Lera, Rosana Álvarez, and José M. Aurrecoechea.
Chemistry - A European Journal; 2013 19 (41), 13893–13900

11.-Total Synthesis of Enantiopure Pyrrhoxanthin: Alternative Methods for the Stereoselective Preparation of 4-Alkylidenebutenolides
Belén Vaz, Leticia Otero, Rosana Álvarez, Ángel R. de Lera
Chemistry - A European Journal; 2013 19 (39), 13065–13074

10.- Adamantyl Arotinoids That Inhibit IκB Kinase α and IκB Kinase β.
Paula Lorenzo, María A. Ortiz, Rosana Alvarez, F. Javier Piedrafita, and Angel R. de Lera
ChemMedChem 2013, 8 (7), 1184 – 1198

9.- Macroscale Plasmonic Substrates for Highly Sensitive Surface-Enhanced Raman Scattering.
María Alba, Nicolas Pazos-Perez, Belén Vaz, Pilar Formentin, Moritz Tebbe, Miguel A. Correa-Duarte, Pedro Granero, Josep Ferré-Borrull, Rosana Alvarez, Josep Pallares, Andreas Fery, Angel R. de Lera, Lluis F. Marsal, and Ramón A. Alvarez-Puebla
Angew.Chem.Int.Ed.; 2013, 52, 1 – 6 pags

8.- Regulation of Retinoid-Mediated Signaling Involved in Skin Homeostasis by RAR and RXR Agonists/Antagonists in Mouse Skin.
Janine Gericke, Jan Ittensohn, Johanna Mihály2, Susana A lvarez, Rosana Alvarez, Dániel Töröcsik, Angel R. de Lera, Ralph Rühl
PLOS one, 2013, 8 (4), e62643, 11pags

7.- Total Synthesis of (8R,6'R)-Peridinin-5,8-Furanoxide
Leticia Otero, Belén Vaz, Rosana Álvarez, and Ángel R. de Lera.
Chem. Comm., 2013, xx (yy), zz-zzz online 15 Apr 2013

6.- Aldo–keto reductases in retinoid metabolism: Search for substrate specificity and inhibitor selectivity
Sergio Porté, F. Xavier Ruiz, Joan Giménez, Iago Molist, Susana Alvarez, Marta Domínguez, Rosana Alvarez, Angel R. de Lera, Xavier Parés, Jaume Farrés.
Chemico-Biological Interactions. 2013, 202 (1-3) , 186–194

5.- Palladium-Catalyzed Diorganozinc Conjugate Additions to Enones: Preparative and Computational Studies
Paula Lorenzo, José M. Aurrecoechea, Angel R. de Lera, and Rosana Álvarez.
Eur. J. Org. Chem. vol 2013 (13), 2621-2626

4.- A conjunctive diiodoheptaene for the synthesis of C2-symmetric carotenoids
Noelia Fontán, Belén Vaz, Rosana Alvarez and Angel R. de Lera
Chem. Comm., 2013,49 (26), 2694-2696

3.- Characterization of pericyclic steps in the mechanisms of Gold(I) catalyzed rearrangement of alkynes
Adán González Pérez, Rosana Álvarez, Ángel R. de Lera
WIREs: Computational Molecular Science; 2013; 3 (3) 211-225 (Overview)

2.- Stille Coupling Involving Bulky Groups Feasible with Gold Cocatalyst
Juan del Pozo, Desirée Carrasco, Mónica H. Pérez-Temprano, Max García-Melchor, Rosana Álvarez, Juan A. Casares, and Pablo Espinet
Angew. Chem. Int. Ed. 2013; 52, 1 – 6

1.- Novel Symmetrical Ureas as Modulators of Protein Arginine Methyl Transferases
Noelia Fontán, Patricia García-Domínguez, Rosana Álvarez, Ángel R. de Lera
Bioorganic & Medicinal Chemistry, 2013; 21 ( 7) 2056–2067

 
(TOP)   2012

19.- A DNA Methyltransferase Modulator Inspired by Peyssonenyne Natural Product Structures
Garcia-Dominguez, Patricia; Weiss, Melanie; Lepore, Ilaria; Alvarez, Rosana; Altucci, Lucia; Gronemeyer, Hinrich; de Lera, Angel R.
ChemMedChem 2012. 7 (12) 2101–2112. (also Front Cover)

18.- Indole-Derived Psammaplin A Analogues as Epigenetic Modulators with Multiple Inhibitory Activities
Pereira, Raquel; Benedetti, Rosaria; Perez-Rodriguez, Santiago; Nebbioso, Angela; Garcia-Rodriguez, Jose; Carafa, Vincenzo; Stuhldreier, Mayra; Conte, Mariarosaria; Rodriguez-Barrios, Fatima; Stunnenberg, Hendrik G.; Gronemeyer, Hinrich; Altucci, Lucia; de Lera, Angel R
Journal of Medicinal Chemistry (2012), 55(22), 9467-9491

17.- Advances in drug design with RXR modulators
Vaz, Belen; de Lera, Angel R
Expert Opinion on Drug Discovery (2012), 7(11), 1003-1016

16.- Mechanistic and Sterochemical Insights on the Pt-Catalyzed Rearrangement of Oxiranylpropargylic Esters to Cyclopentenones
Adán B. González-Pérez , Belén Vaz , Olalla Nieto Faza, and Ángel R. de Lera
J. Org. Chem., 2012, 77 (19), pp 8733–8743

15.- Probing a Polar Cluster in the Retinal Binding Pocket of Bacteriorhodopsin by a Chemical Design Approach
Rosana Simón-Vázquez, Marta Domínguez, Víctor A. Lórenz-Fonfría, Susana Álvarez, José-Luís Bourdelande, Ángel R. de Lera, Esteve Padrós, Alex Perálvarez-Marín
PLoS ONE 2012. 7(8): e42447. (9 pags.)

14.- Retinoid Receptors and Therapeutic Applications of RAR/RXR Modulators
Albane le Maire, Susana Alvarez, Pattabhiraman Shankaranarayanan, Angel R de Lera, William Bourguet, Hinrich Gronemeyer
Current Topics in Medicinal Chemistry. 2012. Vol 12 (6), 505-527

13.- Survey of Synthetic Approaches to Natural (Peyssonenynes) and Unnatural Acetoxyenediynes
Patricia García-Domínguez, Rosana Alvarez, Ángel R. de Lera
Eur. J. Org. Chem. 2012, 25, 4762–4782

12.- First total synthesis of dioxepine bastadin 3
Santiago Pérez-Rodríguez, Raquel Pereira-Cameselle and Ángel R. de Lera
Org. Biomol. Chem., 2012, 10, 6945–6950

11.- Retinoic Acid Receptors and their Modulators: Structural and Functional Insights
Albane le Maire, Susana Alvarez, Pattabhiraman Shankaranarayanan, Angel R de Lera, William Bourguet, Hinrich Gronemeyer
Vitamin A and Carotenoids, 2012, 417-437. Editor(s): Victor R Preedy. ISBN: 978-1-84973-550-6. CHAPTER 24.

10.- Stereoselective Synthesis by Olefin Metathesis and Characterization of n-Carotene (7,8,7',8'-tetrahydro-ß,ß-carotene)
Fontán N, Álvarez R, de Lera AR
Journal of Natural Products 2012, 75, 975-979

9.- Modulation of RXR function through ligand design
Pérez E, Bourguet W, Gronemeyer H, de Lera AR
Biochimica et Biophysica Acta 2012, 1821, 57–69

8.- Strong Metallophilic Interactions in the Palladium Arylation by Gold Aryls
Pérez-Temprano MH, Casares JA, de Lera AR, Álvarez R, Espinet P.
Angew Int. Ed. Chem., 2012, 51 (20), 4917-4920

7.- Characterization of [8-ethyl]-chlorophyll c3 from Emiliania huxleyi
Álvarez S, Zapata M, Garrido JL, Vaz B
Chemical Communication, 2012, 48, 5500-5502

6.- DFT-Based Insights into Pd -Zn Cooperative Effects in Oxidative Addition and Reductive Elimination Processes Relevant to Negishi Cross-Couplings
González-Pérez AB, Álvarez R, Faza ON, Lera AR, Aurrecoechea JM
Organometallics, 2012, 31, 2053- 2058

5.- New synthetic approach to paullones and characterization of their SIRT1 inhibitory activity
Soto S, Vaz E, Dell’Aversana C, Álvarez R, Altucci L, de Lera AR.
Org. Biomol. Chem., 2012, 10, 2101-2112

4.- Palladium-Catalyzed Intermolecular C(sp3)-H Amidation
Iglesias A, Alvarez R, de Lera AR, Muñiz K
Angew Int. Ed. Chem., 2012, 51, 2225-2228.

3.- Stereocontrolled synthesis of (S )-9- cis-4-oxo-13,14-dihydroretinoic acid
Domínguez M, Alvarez S, Alvarez R, de Lera AR.
Tetrahedron, 2012, 68, 1756-1761

2.- Synthesis of Tetrahydrodibenzofuran and Tetrahydrophenanthridinone Skeletons by Intramolecular Nucleopalladation/Oxidative Heck Cascades
Martínez C,Aurrecoechea JM, Madich Y,Denis JG, de Lera AR, Álvarez R.
European Journal of Organic Chemistry 2012, 99-106.

1.- A general LbL strategy for the growth of pNIPAM microgels on Au nanoparticles with arbitrary shapes
Fernández-López C,Pérez-Balado C, Pérez-Juste,Pastoriza-Santos, de Lera AR, Liz-Marzán LM.
Soft Matter 2012, 8 (15), 4165–4170

 
(TOP)   2011

17.- Death Receptor Pathway Activation and Increase of ROS Production by the Triple Epigenetic Inhibitor UVI5008
Nebbioso A.; Pereira R, Khanwalkar H, Matarese F, Garcia-Rodriguez J, Miceli M, Logie C, Kedinger V, Ferrara F, Stunnenberg HG, de Lera AR, Gronemeyer H, Altucci L.
Molecular Cancer Therapeutics 2011, 10, 2394-2404

16.- Epigenetic Multiple Modulators
Álvarez R, Altucci L, Gronemeyer H, de Lera AR
Current Topics in Medicinal Chemistry 2011, 11, 2749-2787

15.- Synthesis of C40-Symmetrical Fully-Conjugated Carotenoids by Olefin Metathesis
Fontán N, Domínguez M, Álvarez R, de Lera AR.
European Journal of Organic Chemistry 2011, 6704-6712.

14.- Residual Dipolar Coupling Enhanced NMR Spectroscopy and Chiroptics: A Powerful Combination for the Complete Elucidation of Symmetrical Small Molecules
Pérez-Balado C, Sun H, Griesinger c, de Lera AR, Navarro-Vázquez A.
Chemistry European Journal, 2011, 17, 11983-11986.

13.- Total synthesis of the proposed structures of the DNA methyl transferase inhibitors peyssonenynes, and structural revision of peyssonenyne B
García-Domínguez P, Lepore I, Erb C, Gronemeyer H, Altucci L, Álvarez R and de Lera AR.
Organic & Biomolecular Chemistry, 2011, 9, 6979-6987.

12.- DFT-Based Mechanistic Insights Into Noble Metal-Catalyzed Rearrangement of Propargylic Derivatives: Chirality Transfer Processes
Nieto Faza O. and de Lera AR.
Topics in Current Chemistry, 2011, 302, 81-130.

11.- Bond Ellipticity As a Measure of Electron Delocalization in Structure and Reactivity
Silva López C. and de Lera AR.
Current Organic Chemistry, 2011, 15, 3576-3593.

10.- Epigenetic Profiling of the Antitumor Natural Product Psammaplin A and Its Analogues
García-Rodríguez J, Franci G, Pereira R, Benedetti R, Nebbioso A, Rodríguez-Barrios F, Gronemeyer H, Altucci L, de Lera AR.
Bioorganic & Medicinal Chemistry 2011; 19, 3637-3649

9.- Design and Stereoselective Synthesis of Retinoids with Ferrocene or N-Butylcarbazole Pharmacophores that Induce Post-Differentiation Apoptosis in Acute Promyelocytic Leukemia Cells
Ivanova D, Gronemeyer H, de Lera AR
ChemMedChem 2011, 6, 1-13

8.- Computational Study of the Intramolecular Pericyclic Reactions of Aldazines and Some Pseudopericyclic Variants
González-Pérez AB, Souto JA, Silva-López C, de Lera AR
Eur. JOC 2011, 16, 2933-2939

7.- Retinoid X Receptor Gamma Is Implicated in Docosahexaenoic Acid Modulation of Despair Behaviors and Working Memory in Mice
Wietrzych-Schindler M, Szyszka-Niagolov M, Ohta K, Endo Y, Pérez E, de Lera AR, Chambon P, Krezel W
Biol Psychiatry 2011, 69, 788-794

6.- Retinoid-Independent Motor Neurogenesis From Human Embryonic Stem Cells Reveals A Medial Columnar Ground State
Patani R, Hollins AJ, Wishart TM, Puddifoot CA, Álvarez S, de Lera AR, Wyllie DJA, Compston DAS, Pedersen RA, Gillingwater TH, Hardingham GE, Allen ND, Chandran S.
Nature Comm. 2011; 2, article 214, 10 pages

5.- On the Memory of Chirality in Gold(I)-Catalyzed Intramolecular Carboalkoxylation of Alkynes
Nieto-Faza O, Silva-Lopez C, de Lera AR
JOC 2011, 76, 3791-3796

4.- Enantioselective Conjugate Addition of Nitro Compounds to alpha,beta-Unsaturated Ketones: An Experimental and Computational Study.
Manzano R, Andrés JM, Álvarez R, Muruzábal MD, de Lera AR, Pedrosa R.
Chemistry Eur. J. 2011; 17 (21) 5931-5938

3.- Separation of regioisomers and enantiomers of underivatized saturated and unsaturated fatty acid monoacylglycerols using enantioselective HPLC.
García P, Franco P, Alvarez R. de Lera AR.
J. Sep. Sci. 2011, 34, 999-1003

2.- Production of hemicellulosic sugars from Pinus pinaster wood by sequential steps of aqueous extraction and acid hydrolysis.
González-Muñoz JM, Alvarez R, Santos V, Parajó JC.
Wood Sci Technol 2011, 46, 271-285

1.- Retinoic acid receptor modulators: a perspective on recent advances and promises.
Alvarez S, Bourguet W, Gronemeyer H, de Lera AR.
Expert Opin Ther Pat. 2011, 21: 55-63.

 
(TOP)   2010

15.- Concise total synthesis and structural revision of (+)-pestalazine B.
Pérez-Balado C, de Lera AR.
Org Biomol Chem. 2010 Nov 21;8(22):5179-86.

14.- Inverse agonists and antagonists of retinoid receptors.
Bourguet W, de Lera AR, Gronemeyer H.
Methods Enzymol. 2010, 485:161-95.

13.- A General Synthesis of Alkenyl-Substituted Benzofurans, Indoles, and Isoquinolones by Cascade Palladium-Catalyzed Heterocyclization/Oxidative Heck Coupling
Rosana Alvarez, Claudio Martínez, Youssef Madich, J. Gabriel Denis,José M. Aurrecoechea, and Angel R. de Lera
Chem. Eur. J. 2010, 16, 12746.

12.- Nolz1 promotes striatal neurogenesis through the regulation of retinoic acid signaling
Noelia Urbán, Raquel Martín-Ibáñez, Cristina Herránz, Miriam Esgleas, Empar Crespo, Mónica Pardo1, Iván Crespo-Enríquez, Héctor R Méndez-Gómez, Ronald Waclaw, Christina Chatzi, Susana Alvarez, Rosana Alvarez, Gregg Duester, Kenneth Campbell, Angel R de Lera, Carlos Vicario-Abejón, Salvador Martínez, Jordi Alberch, Josep M Canals
Neural Development 2010, 5:21

11.- New Anacardic Acid-Inspired Benzamides, Histone Lysine Acetyltransferase Activators
José A. Souto, Rosaria Benedetti, Kattarina Otto, Marco Miceli, Rosana Alvarez, Lucia Altucci, and Angel R. de Lera
ChemMedChem 2010, 5, 1530 - 1540

10.- Synthesis of Diverse Indole-Containing Scaffolds by Gold(I)-Catalyzed Tandem Reactions of 3-Propargylindoles Initiated by 1,2-Indole Migrations: Scope and Computational Studies
Roberto Sanz, Delia Miguel, Mukut Gohain, Patricia García-García, Manuel A. Fernández-Rodríguez, Adán González-Pérez, Olalla Nieto-Faza, Angel R. de Lera, and Félix Rodríguez
Chem. Eur. J. 2010, 16, 9818 – 9828.

Corrigendum: Synthesis of Diverse Indole-Containing Scaffolds by Gold(I)-Catalyzed Tandem Reactions of 3-Propargylindoles Initiated by 1,2-Indole Migrations: Scope and Computational Studies Chem. Eur. J. 2011,17, 13117.

9.- Competing Thermal Electrocyclic Ring-Closure Reactions of (2Z)-Hexa-2,4,5-trienals and Their Schiff Bases. Structural, Kinetic, and Computational Studies.
José A. Souto, Martín Pérez, Carlos Silva López, Rosana Alvarez, Alicia Torrado and Angel R. de Lera
The Journal of Organic Chemistry, 2010 vol 75 (13), 4453-4462

8.- A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor
Albane le Maire, Catherine Teyssier, Cathie Erb, Marina Grimaldi, Susana Alvarez, Angel R de Lera, Patrick Balaguer, Hinrich Gronemeyer, Catherine A Royer, Pierre Germain and William Bourguet
Nature Structural & Molecular Biology, 2010, Vol 17, 801–807

7.- A DFT Study of the Effect of the Ligands in the Reductive Elimination from Palladium Bis(allyl) Complexes
Martín Pérez-Rodríguez, Ataualpa A. C. Braga, Angel R. de Lera, Feliu Maseras, Rosana Alvarez, and Pablo Espinet
Organometallics 2010, 29 (21), 4983–4991

6.- Synthesis and Biological Characterization of the Histone Deacetylase Inhibitor Largazole and C7- Modified Analogues
José A. Souto, Esther Vaz, Ilaria Lepore, Ann-Christin Poeppler, Gianluigi Franci, Rosana Alvarez, Lucia Altucci, and Angel R. de Lera
J. Med. Chem. 2010, 53, 4654–4667

5.- Determination of the geometry of acetoxyendiynes and acetoxyenynes by NMR heteronuclear 13C–1H scalar couplings and 13C NMR chemical shifts. Structural assignment of the oxylipin natural products peyssonenynes A and B.
Patricia García, Manuel Martín-Pastor, Angel R. de Lera and Rosana Alvarez
Magn. Reson. Chem. 2010, 48, 543–549

4.- Retinoic acid signaling targets Hox genes during the amphioxus gastrula stage: insights into early anterior-posterior patterning of the chordate body plan
Demian Koop, Nicholas D. Holland, Marie Sémon, Susana Alvarez, Angel R. de Lera, Vincent Laudet, Linda Z. Holland and Michael Schubert.
Developmental Biol. 2010 Feb 1;338(1):98-106

3.- Understanding abnormal retinoid signaling as a causative mechanism in congenital diaphragmatic hernia.
Clugston, R. D.; Zhang, W.; Alvarez, S.; de Lera, A. R.; Greer J. J.
Am. J. Resp. Cell Mol. Biol. 2010 Mar; 42(3):276-85

2.- Increased adiposity in the retinol saturase-knockout mouse.
Alexander R. Moise, Glen P. Lobo, Susana Alvarez, Marta Domínguez, Rosana Alvarez, Kris Flask, Angel R. de Lera, Johannes von Lintig, and Krzysztof Palczewski.
FASEB Journal (2010), 24(4), 1261-1270

1.- FTY720 Stimulates 27-Hydroxycholesterol Production and Confers Atheroprotective Effects in Human Primary Macrophages
Tomas Blom, Nils Bäck, Aino-Liisa Mutka, Robert Bittman, Zaiguo Li, Angel de Lera, Petri T. Kovanen, Ulf Diczfalusy, Elina Ikonen.
Circulation Research. 2010;106:720-729

 
(TOP)   2009

23.- Retinoic acid and Wnt/β-catenin have complementary roles in anterior/posterior patterning embryos of the basal chordate amphioxus
Takayuki Onai, Hsiu-Chin Lin, Michael Schubert, Demian Koop, Peter W. Osborne, Susana Alvarez, Rosana Alvarez, Nicholas D. Holland and Linda Z. Holland
Developmental Biology, 2009, Volume 332, Issue 2, Pages 223-233

22.- Selective, potent PPARγ agonists with cyclopentenone core structure
M. Paz Otero, Efrén Pérez Santín, Fátima Rodríguez-Barrios, Belén Vaz and Angel R. de Lera
Bioorg. Med. Chem. Lett.,2009, 19, 1883–1886.

21.- Activation of retinoic acid receptors by dihydroretinoids
Alexander R. Moise, Susana Alvarez, Marta Domínguez, Rosana Alvarez, Marcin Golczak, Glenn P. Lobo, Johannes von Lintig, Angel R. de Lera, and Krzysztof Palczewski.
Molecular Pharmacol. 2009 76(6) 1228-1237

20.- C3 Halogen and C8’’ Substituents on Stilbene Arotinoids Modulate Retinoic Acid Receptor Subtype Function.
Susana Alvarez, Harshal Khanwalkar, Rosana Alvarez, Cathie Erb, Claudio Martínez, Fátima Rodríguez-Barrios, Pierre Germain, Hinrich Gronemeyer, and Angel R. de Lera.
ChemMedChem 2009, 4, 1630 – 1640.

19.- Total synthesis of the natural isoprenylcysteine carboxyl methyltransferase inhibitor spermatinamine.
José García, Raquel Pereira, Angel R. de Lera.
Tetrahedron Letters 2009, 50, 5028–5030.

18.- Stereocontrolled and Versatile Total Synthesis of Bispyrrolidinoindoline Diketopiperazine Alkaloids: Structural Revision of the Fungal Isolate (+)-Asperdimin
Carlos Pérez-Balado, Paula Rodríguez-Graña, and Angel R. de Lera
Chem. Eur. J. 2009, 15, 9928 – 9937.

17.- Growth Factor-Antagonized Rexinoid Apoptosis Involves Permissive PPARg/RXR Heterodimers to Activate the Intrinsic Death Pathway by NO.
Pattabhiraman Shankaranarayanan, Aurélie Rossin, Harshal Khanwalkar, Susana Alvarez, Rosana Alvarez, Annica Jacobson, Angela Nebbioso, Angel R. de Lera, Lucia Altucci, and Hinrich Gronemeyer
Cancer Cell 2009, 16, 220–231.

16.- Modulating Retinoid X Receptor with a Series of (E)-3-[4-Hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic Acids and Their 4-Alkoxy Isomers.
Efrén Pérez Santín, Pierre Germain, Fabien Quillard, Harshal Khanwalkar, Fátima Rodríguez-Barrios, Hinrich Gronemeyer, Ángel R. de Lera and William Bourguet
J. Med. Chem. 2009, 52(10), 3150–3158.

15.- Retinoid Receptor Subtype-Selective Modulators Through Synthetic Modifications of RARγ Agonists.
Susana Álvarez, Rosana Álvarez, Harshal Khanwalkar, Pierre Germain, Géraldine Lemaire, Fátima Rodríguez-Barrios, Hinrich Gronemeyer, Ángel R. de Lera
Bioorganic & Medicinal Chemistry, 2009, 17(13), 4345-4359.

14.- Highly Potent Naphthofuran-Based Retinoic Acid Receptor Agonists
Efrén Pérez Santín, Harshal Khanwalkar, Johannes Voegel, Pascal Collette, Pascale Mauvais, Hinrich Gronemeyer, Ángel R. de Lera
ChemMedChem, 2009, 4(5), 780-791.

13.- Pyrazine Arotinoids with Inverse Agonist Activities on the Retinoid and Rexinoid Receptors
José García, Harshal Khanwalkar, Raquel Pereira, Cathie Erb, Johannes J. Voegel, Pascal Collette, Pascale Mauvais, William Bourguet, Hinrich Gronemeyer, Ángel R. de Lera.
ChemBioChem, 2009, 10(7), 1252-1259.

12.- Regulation of Hoxb4 induction after neurulation by somite signal and neural competence
Gayana S Amirthalingam, Sara Howard, Susana Alvarez, Angel R de Lera, and Nobue Itasaki
BMC Dev Biol. 2009; 9: 17.

11.- Regio-, Peri-, and Torquoselectivity in Hydroxy Heptatrienyl Cation Electrocyclizations: The Iso/Homo-Nazarov Reaction
Olalla Nieto Faza, Carlos Silva López, Rosana álvarez, and ángel R. de Lera
Chem. Eur. J. 2009, 15(8), 1944 - 1956

10.- The C-C Reductive Elimination in Palladium Complexes, and the Role of Coupling Additives. A DFT Study Supported by Experiment.
Martín Pérez-Rodríguez, Ataualpa A. C. Braga, Max Garcia-Melchor, Mónica H. Pérez-Temprano, Juan A. Casares,Gregori Ujaque, Angel R. de Lera,Rosana álvarez, Feliu Maseras and Pablo Espinet
J. Am. Chem. Soc. 2009, 131(10), 3650-3657

9.- Palladium-Catalyzed Sequential Oxidative Cyclization/Coupling of 2-Alkynylphenols and Alkenes: A Direct Entry into 3-Alkenylbenzofurans"
Martínez, Claudio; Aurrecoechea, José; álvarez, Rosana.
Org Lett 2009, 11 (5), pp 1083–1086

8.- Aldo-keto reductases from the AKR1B subfamily: Retinoid specificity and control of cellular retinoic acid levels.
Xavier Ruiz; Oriol Gallego.; Albert Ardèvol.; Armando Moro.; Marta Domínguez.; Susana Alvarez.; Rosana Alvarez.; Angel R de Lera.; Carme Rovira.; Ignacio Fita.; Xavier Parés.; Jaume Farrés
Chemico-Biological Interactions 2009, 178(1-3) 171–177

7.- Structural Coupling of 11-cis-7-Methyl-retinal and Amino Acids at the Ligand Binding Pocket of Rhodopsin.
Mònica Aguilà, Darwin Toledo, Margarita Morillo, Marta Dominguez, Belén Vaz, Rosana Alvarez, Angel R. de Lera, Pere Garriga.
Photochemistry and Photobiology 2009, 85(2) March/April, 485-493

6.- Highly Twisted Adamantyl Arotinoids: Synthesis, Antiproliferative Effects and RXR Transactivation Profiles
Santiago Pérez-Rodríguez, Maria A. Ortiz, Raquel Pereira, Fátima Rodríguez-Barrios, Angel R. de Lera and F. Javier Piedrafita
European Journal of Medicinal Chemistry, 2009, 44 (6), 2434-2446.

5.- Isomer-specific effects of conjugated linoleic acid on gene expression in RAW 264.7
Yunkyoung Lee, Jerry T. Thompson, Angel R. de Lera and John P. Vanden Heuvel
J. Nutrit. Biochem., 2009, Volume 20 Issue 11, Pages 848-59, 859.e1-5

4.- Torquoselectivity in the electrocyclic ring-opening of cyclopropyl anions
Faza, O.N., Silva López, C., González-Pérez, A.B., Pérez-Rodríguez, M., De Lera, A.R.
Journal of Physical Organic Chemistry, 2009, 22, 378-385

3.- Mechanism of the gold-catalyzed rearrangement of (3-acyloxyprop-1-ynyl) oxiranes: A dual role of the catalyst
Pérez, A.G., Silva López, C., Marco-Contelles, J., Faza, O.N., Soriano, E., De Lera, A.R.
Journal of Organic Chemistry, 2009, 74, 2982-2991

2.- Electrocyclic ring opening of charged cis-bicyclo[3.2.0]heptadiene and heterocyclic derivatives. the anti-Woodward-Hoffmann quest (II)
Silva López, C., Faza, O.N., De Lera, A.R.
Journal of Organic Chemistry, 2009, 74, 2396-2402

1.- Complex thermal behavior of 11-cis-retinal, the ligand of the visual pigments
Silva López, C., Alvarez, R., Domínguez, M., Faza, O.N., De Lera, A.R.
Journal of Organic Chemistry, 2009, 74, 1007-1013

 
(TOP)   2008

14.- NOVEL DERIVATIVES OF PSAMMAPLIN A, A METHOD FOR THEIR SYNTHESIS AND THEIR USE FOR THE PREVENTION OR TREATMENT OF CANCER
Gronemeyer, Hinrich; Altucci, Lucia; De Lera, Angel; Stunnenberg, Hendrik Gerard.
PCT/IB2008/001887 (pub. 2008/10/23), WO2008125988-56pp .

13.- Derivatives of psammaplin A, a method for their synthesis and their use for the prevention or treatment of cancer
Gronemeyer, Hinrich; De Lera, Angel; Altucci, Lucia.
Eur. Pat. Appl. 07290253.9 (published 2008/09/03, Bulletin 2008/36), EP1964835A1-32pp .

12- Expedient Total Syntheses of WIN 64745 and WIN 64821
Carlos Pérez-Balado and Angel R. de Lera
Org Lett. 2008 Sep 4;10(17):3701-4.

11.- New retinoid chemotypes: 9-cis-Retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists.
Susana Álvarez, Yolanda Pazos-Randulfe, Harshal Khanwalkar, Pierre Germain, Rosana Álvarez, Hinrich Gronemeyer, and ángel R. de Lera.
Bioorg Med Chem. 2008 Nov 15;16(22):9719-28.

10.- Stereoselective Stille Coupling of Enantiopure Haloallenes and Alkenylstannanes for the Synthesis of Allenyl Carotenoids. Experimental and Computational Studies
BelénVaz, Raquél Pereira, Martín Pérez, Rosana Álvarez, Angel R de Lera.
J. Org. Chem., 2008, 73(17), 6534-6541.

9.- Nuclear receptor ligand binding domains: reduction of helix H12 dynamics to favor crystallization
Virginie Nahoum, Alexandra Lipski, Fabien Quillard, Jean-François Guichou, Yvan Boublik, Efrén Pérez, Pierre Germain, Angel R. de Lera, and William Bourguet
Acta Cryst. Sect. F , 2008, F64, 614-616.

8.- Inhibition of IκB Kinaseβ and Anticancer Activities of Novel Chalcone Adamantyl Arotinoids
Paula Lorenzo, Rosana Alvarez, Maria A. Ortiz, Susana Alvarez, F. Javier Piedrafita and Angel R. de Lera
J. Med. Chem., 51 (17), 5431–5440, 2008.

7.- The Associative Transmetalation in the Stille Cross-Coupling Reaction to Form Dienes: Theoretical Insights into the Open Pathway.
Rosana Álvarez, Martín Pérez, Olalla Nieto Faza and Angel R. de Lera.
Organometallics, 27 (14), 3378–3389, 2008.

6.- Synthesis of Benzamides Related to Anacardic Acid and Their Histone Acetyltransferase (HAT) Inhibitory Activities
José A. Souto, Mariarosaria Conte, Rosana Álvarez, Angela Nebbioso, Vincenzo Carafa, Lucia Altucci, and Angel R. de Lera
ChemMedChem, Volume 3 Issue 9, Pages 1435 - 1442, 2008.

5.- Photochromic polymer films based on a 14-F bacteriorhodopsin derivative
Anna Druzhko , Rosana Álvarez and Angel R. de Lera
J. Biomater. Sci. Polymer Edn, Vol. 19, No. 12, pp. 1585-1595 (2008)

4.- Retinoic acid analogues inhibit Human Herpesvirus 8 replication. http://www.intmedpress.com/serveFile.cfm?sUID=2b43af61-e6a7-486a-b572-d68d3f72a9d8
Elisabetta Caselli, Galvan Monica, Fabio Santoni, Susana Alvarez, Angel R. de Lera, Diana Ivanova, Hinrich Gronemeyer, Arnaldo Caruso, Massimo Guidoboni, Enzo Cassai, Riccardo Dolcetti, and Dario Di Luca
Antiviral Therapy 2008, 13(2): 199-209

3.- Stereospecificity of Retinol Saturase: Absolute Configuration, Synthesis and Biological Evaluation of Dihydroretinoids.
Alexander R. Moise, Marta Domínguez, Susana Alvarez, Rosana Alvarez, Michael Schupp, Ana G. Cristancho, Philip D. Kiser, Angel R. de Lera, Mitchell A. Lazar, Krzysztof Palczewski
J. Am. Chem. Soc., 2008, 130(4), 1154-1155.

2.- Characterization of the Switch in the Mechanism of an Intramolecular Diels-Alder Reaction.
Silva Lopez, Carlos; Nieto Faza, Olalla; de Lera, Angel R..
Journal of Organic Chemistry (2008), 73(2), 467-473.

1.- Mechanistic Insights into the Stereocontrolled Synthesis of Hexahydropyrrolo[2,3-b]indoles by Electrophilic Activation of Tryptophan Derivatives.
Silva Lopez, Carlos; Perez-Balado, Carlos; Rodriguez-Grana, Paula; de Lera, Angel R..
Organic Letters, 10 (1), 77 -80, 2008.

 
(TOP)   2007

18.- Structural basis for the high all-trans retinaldehydr reductase activity of the tumor marker AKR1B10
Oriol Gallego, F. Xavier Ruiz, Albert Ardèvol, Marta Domínguez, Rosana Alvarez, Angel R. de Lera, Carme Rovira, Jaume Farrés, Ignacio Fita and Xavier Parés
Proceedings of the National Academy of Sciences of the United States of America, (2007), 104(52), 20764

17.- Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function.
Nahoum, Virginie; Perez, Efren; Germain, Pierre; Rodriguez-Barrios, Fatima; Manzo, Fabio; Kammerer, Sabrina; Lemaire, Geraldine; Hirsch, Oliver; Royer, Catherine A.; Gronemeyer, Hinrich; de Lera, Angel R.; Bourguet, William.
Proceedings of the National Academy of Sciences of the United States of America (2007), 104(44), 17323-17328.

16.- Deuterium exchange and mass spectrometry reveal the interaction differences of two synthetic modulators of RXRa LBD.
Yan, Xuguang; Perez, Efren; Leid, Mark; Schimerlik, Michael I.; De Lera, Angel R.; Deinzer, Max L.
Protein Science (2007), 16(11), 2491-2501.

15.- Rapid, nongenomic actions of retinoic acid on phosphatidylinositol-3-kinase signaling pathway mediated by the retinoic acid receptor.
Masia, Susana; Alvarez, Susana; de Lera, Angel R.; Barettino, Domingo.
Molecular Endocrinology (2007), 21(10), 2391-2402.

14.- RAR and RXR modulation in cancer and metabolic disease.
Altucci, Lucia; Leibowitz, Mark D.; Ogilvie, Kathleen M.; de Lera, Angel R.; Gronemeyer, Hinrich.
Nature Reviews Drug Discovery (2007), 6(10), 793-810.

13.- Design of selective nuclear receptor modulators: RAR and RXR as a case study.
de Lera, Angel R.; Bourguet, William; Altucci, Lucia; Gronemeyer, Hinrich.
Nature Reviews Drug Discovery (2007), 6(10), 811-820.

12.- Feijoa sellowiana derived natural Flavone exerts anti-cancer action displaying HDAC inhibitory activities.
Bontempo, Paola; Mita, Luigi; Miceli, Marco; Doto, Antonella; Nebbioso, Angela; De Bellis, Floriana; Conte, Mariarosaria; Minichiello, Annunziata; Manzo, Fabio; Carafa, Vincenzo; Basile, Adriana; Rigano, Daniela; Sorbo, Sergio; Castaldo Cobianchi, Rosa; Schiavone, Ettore Mariano; Ferrara, Felicetto; De Simone, Mariacarla; Vietri, MariaTeresa; Cioffi, Michele; Sica, Vincenzo; Bresciani, Francesco; de Lera, Angel R.; Altucci, Lucia; Molinari, Anna Maria.
International Journal of Biochemistry & Cell Biology (2007), 39(10), 1902-1914.

11.- Structure, function and modulation of retinoic acid receptor beta, a tumor suppressor.
Alvarez, Susana; Germain, Pierre; Alvarez, Rosana; Rodriguez-Barrios, Fatima; Gronemeyer, Hinrich; De Lera, Angel R..
International Journal of Biochemistry & Cell Biology (2007), 39(7-8), 1406-1415.

10.- Electrocyclic ring opening of cis-bicyclo[m.n.0]alkenes: the anti-Woodward-Hoffmann quest.
Lopez, Carlo Silva; Faza, Olalla Nieto; de Lera, Angel R..
Chemistry--A European Journal (2007), 13(17), 5009-5017.

9.- A density functional theory study of the stille cross-coupling via associative transmetalation. The role of ligands and coordinating solvents.
Alvarez, Rosana; Faza, Olalla Nieto; de Lera, Angel R.; Cardenas, Diego J.
Advanced Synthesis & Catalysis (2007), 349(6), 887-906.

8.- Pseudopericyclic design drives antara-antara [1,5] methylene sigmatropic shifts from a stepwise to a concerted mechanism.
Lopez, Carlos Silva; Faza, Olalla Nieto; Souto, Jose A.; Alvarez, Rosana; De Lera, Angel R..
Journal of Computational Chemistry (2007), 28(8), 1411-1416.

7.- Bimetallic Intermediates in the Formation of Nucleophilic Allenylzincs from Allenylpalladiums: A DFT Study.
Alvarez, Rosana; De Lera, Angel R.; Aurrecoechea, Jose M.; Durana, Aritz.
Organometallics (2007), 26(11), 2799-2802.

6.- Bispyridinium Dienes: Histone Deacetylase Inhibitors with Selective Activities.
Perez-Balado, Carlos; Nebbioso, Angela; Rodriguez-Grana, Paula; Minichiello, Annunziata; Miceli, Marco; Altucci, Lucia; de Lera, Angel R..
Journal of Medicinal Chemistry (2007), 50(10), 2497-2505.

5.- Cyclopent-2-en-1-one derivatives as PPAR modulators, their preparation, pharmaceutical and cosmetic compositions, and uses thereof.
De Lera, Angel Rodriguez; Otero Cabredo, Maria Paz.
PCT Int. Appl. (2007), 63pp. WO2007029121 A2 20070315

4.- Sulfoxide-Induced Stereoselection in [1,5]-Sigmatropic Hydrogen Shifts of Vinylallenes. A Computational Study.
Faza, Olalla Nieto; Lopez, Carlos Silva; de Lera, Angel R..
Journal of Organic Chemistry (2007), 72(7), 2617-2624.

3.- Total synthesis of peridinin and related C37-norcarotenoid butenolides.
Vaz, Belen; Dominguez, Marta; Alvarez, Rosana; de Lera, Angel R..
Chemistry--A European Journal (2007), 13(4), 1273-1290.

2.- Preparation of cyclopent-2-en-1-one derivatives as PPAR modulators and their use in cosmetic and pharmaceutical compositions.
De Lera, Angel Rodriguez; Otero, Cabredo Maria Paz.
Fr. Demande (2007), 56pp. FR2888846 A1 20070126

1.- Specificity of Zebrafish Retinol Saturase: Formation of All-trans-13,14-dihydroretinol and All-trans-7,8-dihydroretinol.
Moise, Alexander R.; Isken, Andrea; Dominguez, Marta; De Lera, Angel R.; Von Lintig, Johannes; Palczewski, Krzysztof.
Biochemistry (2007), 46(7), 1811-1820.

 
(TOP)   2006

15.- International union of pharmacology. LXIII. Retinoid X receptors.
Germain, Pierre; Chambon, Pierre; Eichele, Gregor; Evans, Ronald M.; Lazar, Mitchell A.; Leid, Mark; De Lera, Angel R.; Lotan, Reuben; Mangelsdorf, David J.; Gronemeyer, Hinrich.
Pharmacological Reviews (2006), 58(4), 750-772.

14.- International union of pharmacology. LX. Retinoic acid receptors.
Germain, Pierre; Chambon, Pierre; Eichele, Gregor; Evans, Ronald M.; Lazar, Mitchell A.; Leid, Mark; De Lera, Angel R.; Lotan, Reuben; Mangelsdorf, David J.; Gronemeyer, Hinrich.
Pharmacological Reviews (2006), 58(4), 712-725.

13.- Insights into the mechanism of the site-selective sequential palladium-catalyzed cross-coupling reactions of dibromothiophenes/dibromothiazoles and arylboronic acids. Synthesis of PPARb /d agonists.
Pereira, Raquel; Furst, Audrey; Iglesias, Beatriz; Germain, Pierre; Gronemeyer, Hinrich; de Lera, Angel R..
Organic & Biomolecular Chemistry (2006), 4(24), 4514-4525.

12.- The role of the 11-cis-retinal ring methyl substituents in visual pigment formation.
Dominguez, Marta; Alvarez, Rosana; Perez, Martin; Palczewski, Krzysztof; de Lera, Angel R..
ChemBioChem (2006), 7(11), 1815-1825.

11.- A methyl group at C7 of 11-cis-retinal allows chromophore formation but affects rhodopsin activation.
Bosch, Laia; Cordomi, Arnau; Dominguez, Marta; Toledo, Darwin; Morillo, Margarita; Perez, Juan J.; Alvarez, Rosana; de Lera, Angel R.; Garriga, Pere.
Vision Research (2006), 46(27), 4472-4481.

10.- Activity of alcohol dehydrogenase with 11-cis-retinoids and distribution of ADH4 in ocular tissues.
Porte, Sergio; Martras, Silvia; Martinez, Susana E.; Alvarez, Rosana; Gallego, Oriol; Dominguez, Marta; Duester, Gregg; de Lera, Angel R.; Farres, Jaume; Pares, Xavier.
Enzymology and Molecular Biology of Carbonyl Metabolism--12, [International Meeting], 12th, Burlington, VT, United States, July 6-11, 2004 (2006), Meeting Date 2004, 200-207.

9.- The Stille Reaction in the Synthesis of the C37-Norcarotenoid Butenolide Pyrrhoxanthin. Scope and Limitations.
Vaz, Belen; Dominguez, Marta; Alvarez, Rosana; de Lera, Angel R..
Journal of Organic Chemistry (2006), 71(16), 5914-5920.

8.- Cycloisomerization of Activated (2E,4Z)-Heptatrienoate and Its Relevance to Crispatene (Bio)synthesis. A Case of Concerted and Stepwise Uncertainty.
Lopez, Carlos Silva; Faza, Olalla Nieto; Alvarez, Rosana; de Lera, Angel R..
Journal of Organic Chemistry (2006), 71(12), 4497-4501.

7.- Computational Study and Analysis of the Kinetic Isotope Effects of the Rearrangement of cis-Bicyclo[4.2.0]oct-7-ene to cis,cis-Cycloocta-1,3-diene.
Silva Lopez, Carlos; Nieto Faza, Olalla; De Lera, Angel R..
Organic Letters (2006), 8(10), 2055-2058.

6.- Natural and synthetic retinoids: structural bases and biological effects of potential clinical relevance for the prevention and treatment of infection-driven tumors.
Dolcetti, Riccardo; Di Luca, Dario; de Lera, Angel R..
Anti-Infective Agents in Medicinal Chemistry (2006), 5(1), 85-103.

5.- Mechanism of the Gold(I)-Catalyzed Rautenstrauch Rearrangement: A Center-to-Helix-to-Center Chirality Transfer.
Nieto Faza, Olalla; Silva Lopez, Carlos; Alvarez, Rosana; De Lera, Angel R..
Journal of the American Chemical Society (2006), 128(7), 2434-2437.

4.- Computation of vertical excitation energies of retinal and analogs: Scope and limitations.
Lopez, Carlos Silva; Faza, Olalla Nieto; Estevez, Susana Lopez; De Lera, Angel R..
Journal of Computational Chemistry (2006), 27(1), 116-123.

3.- Synthesis of enantiopure C3- and C4-hydroxyretinals and their enzymatic reduction by ADH8 from Xenopus laevis.
Dominguez, Marta; Alvarez, Rosana; Borras, Emma; Farres, Jaume; Pares, Xavier; De Lera, Angel R..
Organic & Biomolecular Chemistry (2006), 4(1), 155-164.

2.- Computational Characterization of a Complete Palladium-Catalyzed Cross-Coupling Process: The Associative Transmetalation in the Stille Reaction.
Alvarez, Rosana; Nieto Faza, Olalla; Silva Lopez, Carlos; de Lera, Angel R..
Organic Letters (2006), 8(1), 35-38.

1.- Synthesis of the PPARβ/δ-selective agonist GW501516 and C4-thiazole-substituted analogs
Pereira, Raquel; Gaudon, Claudine; Iglesias, Beatriz; Germain, Pierre; Gronemeyer, Hinrich; de Lera, Angel R..
Bioorganic and Medicinal Chemistry Letters (2006), 16(1), 49-54.

 
(TOP)   2005

14.- Mechanistic subtleties in the cyclopentannelation of allenolate allyl carbamates: the origin of the center-to-center chirality transfer
Olalla Nieto, Carlos Silva, Rosana Alvarez and Angel R. de Lera
Chem. Commun. 2005, 4285-4287

13.- Synthesis of N-heteroaryl Retinoids and Their Artificial Bacteriorhodopsins
Susana López, Virginia Rodríguez, Javier Montenegro, Carlos Saá Rosana Álvarez, Carlos Silva, Angel R. de Lera, Rosana Simón, Tzvetana Lazarova and Esteve Padrós
ChemBioChem 2005, 6, 2078-2087

12.- Ligand Recognition by RAR and RXR Receptors: Binding and Selectivity
Fredy Sussman and Angel R. de Lera
J. Med. Chem. 2005, 48, 6212-6219

11.- 2-Alkylidenesulfol-3-enes by (Regio and) Stereoselective Cheletropic Addition of SO2 to (Di)vinylallenes
José A. Souto, Carlos Silva, Olalla Nieto Rosana Alvarez and Angel R. de Lera
Org. Lett. 2005, 7, 1565-1568

10.- Simple Diastereoselectivity of the BF3·OEt2-Catalyzed Vinylogous Mukaiyama Aldol Reaction of 2-(Trimethylsiloxy)furans with Aldehydes
Carlos Silva, Rosana Alvarez, Belén Vaz, Olalla Nieto and Angel R. de Lera
J. Org. Chem. 2005, 70, 3654-3659

9.- Design and Synthesis of RXR Modulators
Angel R. de Lera
Actualités de Chimie Thérapeutique, 2005, 31, 21-45

8.- 14-Fluoro-Bacteriorhodopsin Gelation Films for Dynamic Holography Recording
Elena Korchemskaya, Nicolai Burykin, Angel R. de Lera, Rosana Alvarez, Sergey Pirutin and Anna B. Druzhko
Photochemistry and Photobiology, Volume 81 Issue 4, Pages 920 - 923

7.- Tumor-selective action of HDAC Inhibitors involves TRAIL induction in acute myeloid leukemia cells
Angela Nebossio, Nicole Clarke, Paola Bontempo, Emilie Volz, Rosana Alvarez, Ettore M. Schiavone, Alexssandro Weisz, Francesco Bresciani, Angel R. de Lera, Hinrich Gronemeyer and Lucia Altucci
Nature Medicine 2005, 11, 77-84

6.- Effect of Dehydration on Photoinduced Transformation in Gelatin Films Made of WT and D96N 14-Fluoro-bacteriorhodopsin
Anna B. Druzhko, Sergey K. Pirutin, Angel R. de Lera, Rosana Alvarez and Howard, H. Weetall
Appl. Biochem. Biotechnol. 2005, 120, 121-132

5.- The Stille Reaction in the Synthesis of Carotenoid Butenolides: Synthesis of 6'-epi-Peridinin
Belén Vaz, Rosana Alvarez, Reinhard Brückner and Angel R. de Lera
Org. Lett. 2005, 7, 545-548

4.- γ-Allenyl Allyl Benzothiazole Sulfonyl Anions Undergo cis-Selective (Sylvestre) Julia Olefinations
Belén Vaz, José A. Souto, Rosana Alvarez and Angel R. de Lera
Synlett. 2005, 294-298

3.- Characterization of the Interaction between Retinoic Acid Receptor/Retinoid X Receptor (RAR/RXR) Heterodimers and Transcriptional Coactivators through Structural and Fluorescence Anisotropy Studies
Vivian Pogenberg, Jean-François Guichou, Valie Vivat-Hannah, Sabrina Kammerer, Efrén Pérez, Pierre Germain, Angel R. de Lera, Hinrich Gronemeyer, Catherine A. Royer and William Bourguet
J. Biol. Chem. 2005, 280, 1625-1633

2.- Ellipticity: A Convenient Tool to Characterize Electrocyclic Reactions
Carlos Silva, Olalla Nieto, Fernando P. Cossío, Darrin M. York and Angel R. de Lera
Chemistry: Eur. J. 2005, 11, 1734-1738

1.- Pseudorotation Barriers of Biological Oxyphosphoranes: A Challenge for Simulations of Ribozyme Catalysis
Carlos Silva, Olalla Nieto, Darrin M. York and Angel R. de Lera
Chemistry: Eur. J. 2005, 11, 2081-2093

 
(TOP)   2004

13.- The Specicifity of Alcohol Dehydrogenase With cis-Retinoids.
Silvia Martras, Rosana Alvarez, Susana E. Martínez, Dámaso Torres, Oriol Gallego, Gregg Duester, Jaume Farrés, Angel R. de Lera and Xavier Parés
Eur. J. Biochem. 2004, 271, 1660-1670

12.- 14-Fluorobacteriorhodopsin gelatin films: performance at different relative humidities
A. B. Druzhko, S. K. Pirutin, A. R. de Lera, R. Alvarez, S. Alvarez and M. Domínguez
J. Biol. Phys. Chem. 2004, 4, 11-16.

11.- Enantioselective Synthesis of all of the Stereoisomers of (E)-13,14-Dihydroxyretinol (DHR)
Susana Alvarez, Rosana Alvarez and Angel R. de Lera
Tetrahedron:Asymmetry 2004, 15, 839-846

10.- Conrotatory Ring Opening Reactions of Cyclopropyl Anions in Monocyclic and Tricyclic Systems
Olalla Nieto, Carlos Silva, Rosana Alvarez and Angel R. de Lera
Org. Lett. 2004, 6, 901-904

9.- The Woodward-Hoffmann-DePuy rule revisited
Olalla Nieto, Carlos Silva, Rosana Alvarez and Angel R. de Lera
Org. Lett. 2004, 6, 905-908

8.- Pseudorotation of natural and chemically modified biological phosphoranes: implications for RNA catalysis
Carlos Silva, Olalla Nieto, Brent A. Gregersen, X. López, Angel R. de Lera and D. M. York
Chem. Phys. Chem. 2004, 5, 1045-1049

7.- Theoretical Study of the Vinyl Allene Oxide to Cyclopent-2-en-1-one Rearrangement: Mechanism, Torquoselectivity and Solvent Effects
Carlos Silva, Olalla Nieto, Darrin M. York and Angel R. de Lera
J. Org. Chem. 2004, 69, 3635-3644

6.- Theoretical Study of the Electrocyclic Ring Closure of Hydroxypentadienyl Cations
Olalla Nieto, Carlos Silva, Rosana Alvarez and Angel R. de Lera
Chem. Eur. J. 2004, 10, 4324-4333

5.- Rational design of RAR selective agonists revealed by RAR-β crystal structure
Pierre Gemain, Sabrina Kammerer, Efrén Pérez, Carole Peluso-Iltis, David Tortolani, F. Cristopher Zusi, John Starrett, Philippe Lapointe, Jean-Paull Daris, Anne Marinier, Angel R. de Lera, Natasha Rochel, Hinrich Gronemeyer
EMBO Rep. 2004, 5, 877-882

4.- Kinetics of human alcohol dehydrogenase with ring-oxidized retinoids: effect of Tween 80.
Silvia Martras, Rosana Alvarez, Oriol Gallego, Marta Domínguez, Angel R. de Lera, Jaume Farrés and Xavier Parés
Arch. Biochem. Biophys. 2004, 430, 210-217

3.- 9-cis Retinoic Acid Analogues With Bulky Hydrophobic Rings: New RXR-Selective Agonists
Rosana Alvarez, M. Jess Vega, Sabrina Kammerer, Aurèlie Rossin, Pierre Germain, Hinrich Gronemeyer and Angel R. de Lera
Bioorg. Med. Chem. Lett. 2004, 14, 6117-6122

2.- Synthesis of Ring-oxidized Retinoids as Substrates of Mouse Class I Alcohol Dehydrogenase (ADH1)
Marta Domínguez, Rosana Alvarez, Silvia Martras, Jaume Farré, Xavier Parés and Angel R. de Lera
Org. Biomol. Chem. 2004, 2, 3368-3373

1.- Solvolytic Ring Opening Reactions of Cyclopropyl Halides. An Assessment of the Woodward-Hoffmann-DePuy Rule
Olalla Nieto, Carlos Silva, Rosana Alvarez and Angel R. de Lera
J. Org. Chem. 2004, 69, 9002-9010

 
(TOP)   2003

Recent Advances in the Synthesis of Retinoids
Beatriz Domínguez, Rosana Alvarez and Angel R. de Lera
Org. Prep. Proc. Int. 2003, 35, 239-306

9Z- and 11Z-8-Methylretinals for Artificial Visual Pigment Studies. Stereoselective Synthesis, Structure and Binding Modeling
Rosana Alvarez, Marta Domínguez, Yolanda Pazos, Fredy Sussman and Angel R. de Lera
Chem. Eur. J., 2003, 9, 5821-5831

 
(TOP)   2002

Bleaching kinetics of artificial visual pigments with modifications near the ring/polyene chain connection
Istvan Szundi, Angel R. de Lera, Yolanda Pazos, Rosana Alvarez, Marco Oliana, Mordechai Sheves, James W. Lewis and David S. Kliger
Biochemistry 2002, 41, 2028-2035

Reply to:
Electrocyclization of (Z)-1,2,4,6-Heptatetraene and Its Heterosubstituted Analogs: Pericyclic or Pseudopericyclic?
Angel R. de Lera and Fernando P. Cossío
Angew. Chem. Int. Ed. 2002,41, 1150-1152

Synthesis of Symmetrical Carotenoids by a Two-fold Stille Coupling
Belén Vaz, Rosana Alvarez and Angel R. de Lera
J. Org. Chem. 2002, 67, 5040-5043

Stereoselective Synthesis of Annular 9-cis-Retinoids and Binding Characterization to the Retinoid X Receptor
M. Paz Otero, Alicia Torrado, Yolanda Pazos, Fredy Sussman and Angel R. de Lera
J. Org. Chem. 2002, 67, 5876-5882

Synthesis and Characterization of a New RXR Agonist Based on the 6-tert-Butyl-1,1-dimethylindanyl Structure
Beatriz Domínguez, M. Jesús Vega, Fredy Sussman and Angel R. de Lera
Bioorg. Med. Chem. Lett. 2002, 12, 2607-2609

 
(TOP)   2001

Photoinduced Transformation of 14-F-Bacteriorhodopsin Gelatin Films Based on Both Wild Type and D96N Mutants
Anna B. Druzhko, V.Y. Shakhbazian, Rosana Alvarez, Angel R. de Lera and Howard H. Weetall
Biosystems 2001, 59, 53-60

An Expedient Stereocontrolled Synthesis of 7-cis-Retinoids
Rosana Alvarez, Beatriz Domínguez and Angel R. de Lera
Synth. Commun. 2001, 31, 2083-2087

On the Aromatic Character of Electrocyclic and Pseudopericyclic Reactions: Thermal Cyclization of (2Z)-Hexa-2,4,5-trienals and their Schiff Bases
Angel R. de Lera, Rosana Alvarez, Begoña Lecea, Alicia Torrado and Fernando P. Cossío
Angew. Chem. Int. Ed. 2001, 40, 557-561

A General Synthesis of Alkylpyridines
Beatriz Iglesias, Rosana Alvarez and Angel R. de Lera
Tetrahedron 2001, 57, 3125-3130

Regioselective palladium-catalyzed cross-coupling reactions in the synthesis of novel 2,3-disubstituted thiophene derivatives
Raquel Pereira, Beatriz Iglesias and Angel R. de Lera
Tetrahedron 2001, 57, 7871-7881

Suzuki cross-coupling of meso-dibromoporphyrins for the synthesis of functionalized A2B2 porphyrins
Belén Vaz, Rosana Alvarez, Mar Nieto, Antonio I. Paniello and Angel R. de Lera
Tetrahedron Lett. 2001, 42, 7409-7412

The Suzuki Coupling Reaction in the Stereocontrolled Synthesis of 9-cis-Retinoic Acid and Its Ring-Demethylated Analogues
Yolanda Pazos, Beatriz Iglesias and Angel R. de Lera
J. Org. Chem. 2001, 66, 8483-8489

 
(TOP)   2000

A Pericyclic Cascade to the Stereocontrolled Synthesis of 9-cis-Retinoids
Beatriz Iglesias, Alicia Torrado, and Angel R. de Lera
J. Org. Chem. 2000, 65, 2696-2705

Measurement of Proton Release and Uptake by Analogs of Bacteriorhodopsin
Howard H. Weetall , Anna B. Druzhko, Angel R. de Lera, Rosana Alvarez and Baldwin Robertson
Bioelectrochemistry, 2000, 51, 27-33

Torquoselectivity in the Cationic Cyclopentannelation of (2Z)-Hexa-2,4,5-trienal Acetals
Angel R. de Lera, Beatriz Iglesias, Susana López and Jesús Rodríguez
Chem. Eur. J., 2000, 6, 4021-4033

Stereocontrolled Synthesis of 6-s-cis- and 6-s-trans-Locked 9Z-Retinoids by Hydroxyl-Accelerated Stille Coupling of (Z)-Tri-n-Butylstannylbut-2-en-1-ol and Bicyclic Dienyl Triflates
Beatriz Domínguez, Yolanda Pazos and Angel R. de Lera
J. Org. Chem. 2000, 65, 5917-5925

Isomerization of all-trans-Retinol to cis-Retinols in Bovine Retinal Pigment Epithelial Cells: Dependence on the Specificity of Retinoid-Binding Proteins
J. K. McBee, V. Kuksa, R. Alvarez, Angel R. de Lera, O. Prezhdo, F. Haeseleer, I. Sokal and K. Palczewski
Biochemistry 2000, 39, 11370-11380