2024
- The rice orobanchol synthase catalyzes the hydroxylation of the noncanonical strigolactone methyl 4-oxo-carlactonoate
- Hydrothermal extraction of ulvans from Ulva spp. in a biorefinery approach
- Synthesis and pharmacological characterization of UVI3502, a novel cannabinoid receptor 1 (CB1) antagonist/inverse agonist
- Chromosome-scale pearl millet genomes reveal CLAMT1b as key determinant of strigolactone pattern and Striga susceptibility
- Influence of the Culture Conditions on Camellia sinensis Cell Cultures
- From Acyclic Intramolecular-[4 + 2]- to Transannular Bis-[4 + 2]- Cycloaddition of the Macrodiolide for the Stereoselective Synthesis of the Octahydronaphthalene Core of Polyenic Macrolactam Sagamilactam
- Delving into the Variability of Supramolecular Affinity: Self-Ion Pairing as a Central Player in Aqueous Host-Guest Chemistry
- Stereospecific Indium(III)-Catalysed Tandem Cycloisomerization of Functionalized 1,6-enynes: Scope and Mechanistic Insights
2023
- Unraveling Structure–Performance Relationships in Porphyrin-Sensitized TiO2 Photocatalysts
- Applicability domains of neural networks for toxicity prediction
- Chapter 17 - Inhibitors of Jumonji-C domain-containing histone demethylases
- Human nutritional relevance and suggested nutritional guidelines for vitamin A5/X and provitamin A5/X
- Pneumolysin as a Target for New Therapies Against Pneumococcal Infections: Systematic Review
- State-of-the-art methodological investigation of carotenoid activity and metabolism – from organic synthesis via metabolism to biological activity – exemplified by a novel retinoid signalling pathway
2022
- Bispyrrolidinoindoline Epi(poly)thiodioxopiperazines (BPI-ETPs) and Simplified Mimetics: Structural Determination, Bioactivities and Total Synthesis
- SERS optical accumulators as unified nanoplatforms for tear sampling and sensing in soft contact lenses
- Chemical synthesis in competition with global genome mining and heterologous expression for the preparation of dimeric indole-derived 2,5-dioxopiperazines
- Stereoselective Synthesis of Bisfuranoxide (Aurochrome, Auroxanthin) and Monofuranoxide (Equinenone 5’,8´-epoxide) Carotenoids by Bidirectional Horner-Wadsworth-Emmons Reaction
- Synergistic Antitumoral Effect of Epigenetic Inhibitors and Gemcitabine in Pancreatic Cancer Cells
- Total Synthesis of the Proposed Structure of (-)-Novofumigatamide, Isomers Thereof and Analogues. Part I
- Puzzling Out the Structure of Novofumigatamide: Total Synthesis of Constitutional Isomers. Part II
- Carotenoid Metabolites, their tissue and blood concentrations and further bioactivity via retinoid receptor-mediated signalling
- Review: Presence, distribution and current pesticides used in Spanish agricultural practices
- An alternative, zeaxanthin epoxidase-independent abscisic acid biosynthetic pathway in plants
- Retinoic acid receptor beta protects striatopallidal medium spiny neurons from mitochondrial dysfunction and neurodegeneration
2021
- Influence of elaboration process on chemical, biological, and sensory characteristics of European pennyroyal liqueurs
- Fast 1H-NMR Species Differentiation Method for Camellia Seed Oils Applied to Spanish Ornamentals Plants. Comparison with Traditional Gas Chromatography
- Toxicity prediction based on artificial intelligence: A multidisciplinary overview
- Synthetic Studies on Alotamide A: Construction of N-Demethylalotamide A
- Total synthesis of nahuoic acid A via a putative biogenetic intramolecular Diels–Alder (IMDA) reaction
- Vitamin A5/X controls stress-adaptation and prevents depressive-like behaviors in a mouse model of chronic stress
- On the rearrangements of biologically-relevant vinyl allene oxides to cis-cyclopentenones, ketols, and Favorskii-type carboxylic acids
- Continuous-Flow Preparation of Benzotropolones: Combined Batch and Flow Synthesis of Epigenetic Modulators of the (JmjC)-Containing Domain
- Synthesis of L–Au(I)–CF2H Complexes and Their Application as Transmetalation Shuttles to the Difluoromethylation of Aryl Iodides
- Palladium-Catalyzed Aminocyclization–Coupling Cascades: Preparation of Dehydrotryptophan Derivatives and Computational Study
- Total Synthesis of Homo- and Heterodimeric Bispyrrolidinoindoline Dioxopiperazine Natural Products
- Natural polyenic macrolactams and polycyclic derivatives generated by transannular pericyclic reactions: optimized biogenesis challenging chemical synthesis
- Vitamin A5/X, a New Food to Lipid Hormone Concept for a Nutritional Ligand to Control RXR-Mediated Signaling
- From carotenoid intake to carotenoid blood and tissue concentrations – implications for dietary intake recommendations
2020
- Continuous flow synthesis of lipophilic cations derived from benzoic acid as new cytotoxic chemical entities in human head and neck carcinoma cell lines
- Efficient Mimics for Elucidating Zaxinone Biology and Promoting Agricultural Applications
- Synthesis of C11-to-C14 methyl-shifted all-trans-retinal analogues and their activities on human aldo-keto reductases
- Two-hit wonders: The expanding universe of multitargeting epigenetic agents
- Multicomponent and multicatalytic asymmetric synthesis of furo[2,3-b]pyrrole derivatives: further insights into the mode of action of chiral phosphoric acid catalysts
- Experimental and DFT Study of the [AuAr(AsPh3)]-Catalyzed cis/trans Isomerization of [PdAr2(AsPh3)2] (Ar = C6F5 or C6Cl2F3): Alternative Mechanisms and Its Switch upon Pt for Pd Substitution
- Synthesis of Symmetrical and Nonsymmetrical Polyenes by Iterative and Bidirectional Palladium‐Catalyzed Cross‐Coupling Reactions
- Natural ligands of RXR receptors
- A New Family of Jumonji C Domain-Containing KDM Inhibitors Inspired by Natural Product Purpurogallin
2019
- The influence of in vitro gastrointestinal digestion on the chemical composition and antioxidant and enzyme inhibitory capacities of carob liqueurs obtained with different elaboration techniques
- Effect of carob variety and roasting on the antioxidant capacity, and the phenolic and furanic contents of carob liquors
- Elicitation improves rosmarinic acid content and antioxidant activity in Thymus lotocephalus shoot cultures
- Ligand Design for Modulation of RXR Functions
- Apo-14´-Carotenoic Acid Is a Novel Endogenous and Bioactive Apo-Carotenoid
- Bidirectional Hiyama–Denmark Cross‐Coupling Reactions of Bissilyldeca‐1,3,5,7,9‐pentaenes for the Synthesis of Symmetrical and Non‐Symmetrical Carotenoids
- Improved synthesis of key fragments for the preparation of natural product incednine
- Stereocontrolled synthesis and configurational assignment of (R)-all-trans-11,12-dihydro-3-hydroxyretinol
- Computational studies on the formation of aza-oxypentadienyl intermediates from alkylidene oxaziridines and keteneimine oxides and their conversion to 1,5-dihydropyrrolones
- A Computational Study of Model Parent Systems and Reported Aza‐(Iso)Nazarov/Aza‐(Iso)Piancatelli Electrocyclic Reactions
- Alternative retinoid X receptor (RXR) ligands
- Deciphering the Origin of Enantioselectivity on the Cis-Cyclopropanation of Styrene with Enantiopure Di-chloro,Di-gold(I)-SEGPHOS Carbenoids Generated from Propargylic Esters
2018
- Production method and varietal source influence the volatile profiles of spirits prepared from fig fruits (Ficus carica L.)
- Synthesis and Biological Evaluation of Tripartin, a Putative KDM4 Natural Product Inhibitor, and 1‐Dichloromethylinden‐1‐ol Analogues
- Precursor compounds for providing retinoids of the vitamin A5 pathway and uses thereof
- Regioselective Palladium-Catalyzed Heterocyclization–Sonogashira Coupling Cascades from 2-Alkynylbenzamides and Terminal Alkynes: Experimental and DFT Studies
- Synthesis of apocarotenoids by acyclic cross metathesis and characterization as substrates for human retinaldehyde dehydrogenases
2017
- Mass Spectrometry of Algal Chlorophyll c Compounds
- Indole–Indole Ullmann Cross‐Coupling for CAr–N Bond Formation: Total Synthesis of (–)‐Aspergilazine A
- Synthesis of the octahydronaphthalene core of nahuoic acid A via a B(C6F5)3-catalyzed intramolecular Diels–Alder (IMDA) reaction
- On the regiochemical differences between Pd-catalyzed heterocyclization–allylation and –arylation reactions of alkynylbenzamides: preparation of 4-allyl-isochromen-1-imines and computational study
- Speciation of ZnMe2, ZnMeCl, and ZnCl2 in Tetrahydrofuran (THF), and Its Influence on Mechanism Calculations of Catalytic Processes
- Natural and structure-based RXR ligand scaffolds and their functions
- Structural basis for the inhibition of AKR1B10 by the C3 brominated TTNPB derivative UVI2008
- Lineage-specific duplication of amphioxus retinoic acid degrading enzymes (CYP26) resulted in sub-functionalization of patterning and homeostatic roles
- Rearrangement of vinyl allene oxide geometric isomers to cyclopentenones. Further computational insights with biologically relevant model systems
- Reduced adiponectin expression after high-fat diet is associated with selective up-regulation of ALDH1A1 and further retinoic acid receptor signaling in adipose tissue
- Total synthesis of naturally occurring (+)-psychotriasine and the related tetrahydro-β-carboline, dimeric tryptamines with N–C connectivities
2016
- Epigenetic polypharmacology: from combination therapy to multitargeted drugs
- Relationship between All-trans-13,14-Dihydro Retinoic Acid and Pancreatic Adenocarcinoma
- An Endogenous Mammalian Retinoid X Receptor Ligand, at Last!
- The Negishi Catalysis: Full Study of the Complications in the Transmetalation Step and Consequences for the Coupling Products
- 19,19'-Diacyloxy Signature: An Atypical Level of Structural Evolution in Carotenoid Pigments
- Stereocontrolled synthesis of (S)-9-cis- and (S)-11-cis-13,14-dihydroretinoic acid
- Friedel–Crafts Alkylation of Indoles with p-Quinols: The Role of Hydrogen Bonding of Water for the Desymmetrization of the Cyclohexadienone System
- Evolutionary diversification of retinoic acid receptor (RAR) ligand-binding pocket structure by molecular tinkering
- Exploiting the Multidentate Nature of Chiral Disulfonimides in a Multicomponent Reaction for the Asymmetric Synthesis of Pyrrolo[1,2-a]indoles: A Remarkable Case of Enantioinversion
- TSLP expression in the skin is mediated via RAR?-RXR pathways
2015
- Stereoselective [3+2]-Carbocyclization of Indole Derived Imines and Electron-Rich Alkenes: A Divergent Synthesis of Cyclopenta[b]indole or Tetrahydroquinoline Derivatives
- Structural determinants of the selectivity of 3-benzyluracil-1-acetic acids towards human enzymes aldose reductase and AKR1B10
- Modulation of Retinoic Acid Receptor Subtypes by 5- and 8-Substituted (Naphthalen-2-yl)-based Arotinoids
- 9-cis-13,14-dihydroretinoic acid is an endogenous retinoid acting as RXR ligand in mice
- Evolution of the Role of RA and FGF Signals in the Control of Somitogenesis in Chordates
- Palladium-Catalyzed 6-endo-Selective Oxycyclization–Alkene Addition Cascades of ortho-Alkynylarylcarboxamides and alpha,beta-Unsaturated Carbonyl Compounds
- Organometallic Nucleophiles and Pd: What Makes ZnMe2 Different? Is Au Like Zn?
- Synthesis of labile all-trans-7,8,7’,8’-bis-acetylenic carotenoids by bidirectional Horner-Wadsworth-Emmons condensation
- Synthesis of 7-Alkylidene-7,12-dihydroindolo[3,2-d]benzazepine-6-(5H)-ones (7-Alkylidene-Paullones) by N-cyclization-Oxidative Heck Cascade and Characterization as Sirtuin Modulators
- Palladium Nanoparticle-Loaded Cellulose Paper: A Highly Efficient, Robust, and Recyclable Self-Assembled Composite Catalytic System
2014
- Roles of retinoic acid and Tbx1/10 in pharyngeal segmentation: amphioxus and the ancestral chordate condition
- Silicon particles as trojan horses for potential cancer therapy
- A unifying mechanism for the rearrangement of vinyl allene oxide geometric isomers to cyclopentenones
- Palladium-Catalyzed Regioselective 5-exo-O-Cyclization/Oxidative Heck Cascades from o-Alkynylbenzamides and Electron-Deficient Alkenes
- Dual RXR Agonists and RAR Antagonists Based on the Stilbene Retinoid Scafold
- Total Synthesis and Structural Revision of (–)-Protubonine A and (–)-Protubonine B
- Total Synthesis and Structural Revision of (+)-Cristatumin C
- Enantioselective Synthesis of Hexahydrofuro[3,2-c]quinolines through a Multicatalytic and Multicomponent Process. A New “Aromatic Sandwich” Model for BINOL-Phosphoric Acid Catalyzed Reactions
- Identification of a novel polyfluorinated compound as a lead to inhibit human enzymes aldose reductase and AKR1B10: structure determination of both ternary complexes and implications for drug design
- Functions, Therapeutic Applications, and Synthesis of Retinoids and Carotenoids
2013
- A Practical Protocol for Three-Component One-Pot Stepwise Sonogashira-Heterocyclization/Heck-Couplings
- Catalyst- and Solvent-Dependent Stereodivergence in the Intramolecular Et2Zn/Pd0-Promoted Carbonyl Propargylation: Mechanistic Implications
- Total Synthesis of Enantiopure Pyrrhoxanthin: Alternative Methods for the Stereoselective Preparation of 4-Alkylidenebutenolides
- Adamantyl Arotinoids That Inhibit IκB Kinase α and IκB Kinase β
- Macroscale Plasmonic Substrates for Highly Sensitive Surface-Enhanced Raman Scattering
- Regulation of Retinoid-Mediated Signaling Involved in Skin Homeostasis by RAR and RXR Agonists/Antagonists in Mouse Skin
- Total Synthesis of (8R,6'R)-Peridinin-5,8-Furanoxide
- Aldo–keto reductases in retinoid metabolism: Search for substrate specificity and inhibitor selectivity
- Palladium-Catalyzed Diorganozinc Conjugate Additions to Enones: Preparative and Computational Studies
- A conjunctive diiodoheptaene for the synthesis of C2-symmetric carotenoids
- Characterization of pericyclic steps in the mechanisms of Gold(I) catalyzed rearrangement of alkynes
- Stille Coupling Involving Bulky Groups Feasible with Gold Cocatalyst
- Novel Symmetrical Ureas as Modulators of Protein Arginine Methyl Transferases
2012
- A DNA Methyltransferase Modulator Inspired by Peyssonenyne Natural Product Structures
- Indole-Derived Psammaplin A Analogues as Epigenetic Modulators with Multiple Inhibitory Activities
- Advances in drug design with RXR modulators
- Mechanistic and Sterochemical Insights on the Pt-Catalyzed Rearrangement of Oxiranylpropargylic Esters to Cyclopentenones
- Probing a Polar Cluster in the Retinal Binding Pocket of Bacteriorhodopsin by a Chemical Design Approach
- Retinoid Receptors and Therapeutic Applications of RAR/RXR Modulators
- Survey of Synthetic Approaches to Natural (Peyssonenynes) and Unnatural Acetoxyenediynes
- First total synthesis of dioxepine bastadin 3
- Retinoic Acid Receptors and their Modulators: Structural and Functional Insights
- Stereoselective Synthesis by Olefin Metathesis and Characterization of n-Carotene (7,8,7',8'-tetrahydro-ß,ß-carotene)
- Modulation of RXR function through ligand design
- Strong Metallophilic Interactions in the Palladium Arylation by Gold Aryls
- Characterization of [8-ethyl]-chlorophyll c3 from Emiliania huxleyi
- DFT-Based Insights into Pd -Zn Cooperative Effects in Oxidative Addition and Reductive Elimination Processes Relevant to Negishi Cross-Couplings
- New synthetic approach to paullones and characterization of their SIRT1 inhibitory activity
- Palladium-Catalyzed Intermolecular C(sp3)-H Amidation
- Stereocontrolled synthesis of (S )-9- cis-4-oxo-13,14-dihydroretinoic acid
- Synthesis of Tetrahydrodibenzofuran and Tetrahydrophenanthridinone Skeletons by Intramolecular Nucleopalladation/Oxidative Heck Cascades
- A general LbL strategy for the growth of pNIPAM microgels on Au nanoparticles with arbitrary shapes
2011
- Death Receptor Pathway Activation and Increase of ROS Production by the Triple Epigenetic Inhibitor UVI5008
- Epigenetic Multiple Modulators
- Synthesis of C40-Symmetrical Fully-Conjugated Carotenoids by Olefin Metathesis
- Residual Dipolar Coupling Enhanced NMR Spectroscopy and Chiroptics: A Powerful Combination for the Complete Elucidation of Symmetrical Small Molecules
- Total synthesis of the proposed structures of the DNA methyl transferase inhibitors peyssonenynes, and structural revision of peyssonenyne BOrganic & Biomolecular Chemistry 2011, 9 (20), 6979-6987
- DFT-Based Mechanistic Insights Into Noble Metal-Catalyzed Rearrangement of Propargylic Derivatives: Chirality Transfer Processes
- Bond Ellipticity As a Measure of Electron Delocalization in Structure and Reactivity
- Epigenetic Profiling of the Antitumor Natural Product Psammaplin A and Its Analogues
- Design and Stereoselective Synthesis of Retinoids with Ferrocene or N-Butylcarbazole Pharmacophores that Induce Post-Differentiation Apoptosis in Acute Promyelocytic Leukemia Cells
- Computational Study of the Intramolecular Pericyclic Reactions of Aldazines and Some Pseudopericyclic Variants
- Retinoid X Receptor Gamma Is Implicated in Docosahexaenoic Acid Modulation of Despair Behaviors and Working Memory in Mice
- Retinoid-Independent Motor Neurogenesis From Human Embryonic Stem Cells Reveals A Medial Columnar Ground State
- On the Memory of Chirality in Gold(I)-Catalyzed Intramolecular Carboalkoxylation of Alkynes
- Enantioselective Conjugate Addition of Nitro Compounds to alpha,beta-Unsaturated Ketones: An Experimental and Computational Study
- Separation of regioisomers and enantiomers of underivatized saturated and unsaturated fatty acid monoacylglycerols using enantioselective HPLC
- Production of hemicellulosic sugars from Pinus pinaster wood by sequential steps of aqueous extraction and acid hydrolysis
- Retinoic acid receptor modulators: a perspective on recent advances and promises
2010
- Concise total synthesis and structural revision of (+)-pestalazine B
- Inverse agonists and antagonists of retinoid receptors
- A General Synthesis of Alkenyl-Substituted Benzofurans, Indoles, and Isoquinolones by Cascade Palladium-Catalyzed Heterocyclization/Oxidative Heck Coupling
- Nolz1 promotes striatal neurogenesis through the regulation of retinoic acid signaling
- New Anacardic Acid-Inspired Benzamides, Histone Lysine Acetyltransferase Activators
- Synthesis of Diverse Indole-Containing Scaffolds by Gold(I)-Catalyzed Tandem Reactions of 3-Propargylindoles Initiated by 1,2-Indole Migrations: Scope and Computational Studies
- Competing Thermal Electrocyclic Ring-Closure Reactions of (2Z)-Hexa-2,4,5-trienals and Their Schiff Bases. Structural, Kinetic, and Computational Studies
- A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor
- A DFT Study of the Effect of the Ligands in the Reductive Elimination from Palladium Bis(allyl) Complexes
- Synthesis and Biological Characterization of the Histone Deacetylase Inhibitor Largazole and C7- Modified Analogues
- Determination of the geometry of acetoxyendiynes and acetoxyenynes by NMR heteronuclear 13C–1H scalar couplings and 13C NMR chemical shifts. Structural assignment of the oxylipin natural products peyssonenynes A and B
- Retinoic acid signaling targets Hox genes during the amphioxus gastrula stage: insights into early anterior-posterior patterning of the chordate body plan
- Understanding abnormal retinoid signaling as a causative mechanism in congenital diaphragmatic hernia
- Increased adiposity in the retinol saturase-knockout mouse
- FTY720 Stimulates 27-Hydroxycholesterol Production and Confers Atheroprotective Effects in Human Primary Macrophages
2009
- Retinoic acid and Wnt/β-catenin have complementary roles in anterior/posterior patterning embryos of the basal chordate amphioxus
- Selective, potent PPARγ agonists with cyclopentenone core structure
- Activation of retinoic acid receptors by dihydroretinoids
- C3 Halogen and C8’’ Substituents on Stilbene Arotinoids Modulate Retinoic Acid Receptor Subtype Function
- Total synthesis of the natural isoprenylcysteine carboxyl methyltransferase inhibitor spermatinamine
- Stereocontrolled and Versatile Total Synthesis of Bispyrrolidinoindoline Diketopiperazine Alkaloids: Structural Revision of the Fungal Isolate (+)-Asperdimin
- Growth Factor-Antagonized Rexinoid Apoptosis Involves Permissive PPARg/RXR Heterodimers to Activate the Intrinsic Death Pathway by NO
- Modulating Retinoid X Receptor with a Series of (E)-3-[4-Hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic Acids and Their 4-Alkoxy Isomers
- Retinoid Receptor Subtype-Selective Modulators Through Synthetic Modifications of RARγ Agonists
- Highly Potent Naphthofuran-Based Retinoic Acid Receptor Agonists
- Pyrazine Arotinoids with Inverse Agonist Activities on the Retinoid and Rexinoid Receptors
- Regulation of Hoxb4 induction after neurulation by somite signal and neural competence
- Regio-, Peri-, and Torquoselectivity in Hydroxy Heptatrienyl Cation Electrocyclizations: The Iso/Homo-Nazarov Reaction
- The C-C Reductive Elimination in Palladium Complexes, and the Role of Coupling Additives. A DFT Study Supported by Experiment
- Palladium-Catalyzed Sequential Oxidative Cyclization/Coupling of 2-Alkynylphenols and Alkenes: A Direct Entry into 3-Alkenylbenzofurans"
- ldo-keto reductases from the AKR1B subfamily: Retinoid specificity and control of cellular retinoic acid levels
- Structural Coupling of 11-cis-7-Methyl-retinal and Amino Acids at the Ligand Binding Pocket of Rhodopsin
- Highly Twisted Adamantyl Arotinoids: Synthesis, Antiproliferative Effects and RXR Transactivation Profiles
- Isomer-specific effects of conjugated linoleic acid on gene expression in RAW 264.7
- Torquoselectivity in the electrocyclic ring-opening of cyclopropyl anions
- Mechanism of the gold-catalyzed rearrangement of (3-acyloxyprop-1-ynyl) oxiranes: A dual role of the catalyst
- Electrocyclic ring opening of charged cis-bicyclo[3.2.0]heptadiene and heterocyclic derivatives. the anti-Woodward-Hoffmann quest (II)
- Complex thermal behavior of 11-cis-retinal, the ligand of the visual pigments
2008
- Novel derivatives of psammaplin A, a method for their synthesis and their use for the prevention or treatment of cancer
- Derivatives of psammaplin A, a method for their synthesis and their use for the prevention or treatment of cancer
- Expedient Total Syntheses of WIN 64745 and WIN 64821
- New retinoid chemotypes: 9-cis-Retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists
- Stereoselective Stille Coupling of Enantiopure Haloallenes and Alkenylstannanes for the Synthesis of Allenyl Carotenoids. Experimental and Computational Studies
- Nuclear receptor ligand binding domains: reduction of helix H12 dynamics to favor crystallization
- Inhibition of IκB Kinaseβ and Anticancer Activities of Novel Chalcone Adamantyl Arotinoids
- The Associative Transmetalation in the Stille Cross-Coupling Reaction to Form Dienes: Theoretical Insights into the Open Pathway
- Synthesis of Benzamides Related to Anacardic Acid and Their Histone Acetyltransferase (HAT) Inhibitory Activities
- Photochromic polymer films based on a 14-F bacteriorhodopsin derivative
- Retinoic acid analogues inhibit Human Herpesvirus 8 replication
- Stereospecificity of Retinol Saturase: Absolute Configuration, Synthesis and Biological Evaluation of Dihydroretinoids
- Characterization of the Switch in the Mechanism of an Intramolecular Diels-Alder Reaction
- Mechanistic Insights into the Stereocontrolled Synthesis of Hexahydropyrrolo[2,3-b]indoles by Electrophilic Activation of Tryptophan Derivatives
2007
- Structural basis for the high all-trans retinaldehydr reductase activity of the tumor marker AKR1B10
- Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function
- Deuterium exchange and mass spectrometry reveal the interaction differences of two synthetic modulators of RXRa LBD
- Rapid, nongenomic actions of retinoic acid on phosphatidylinositol-3-kinase signaling pathway mediated by the retinoic acid receptor
- RAR and RXR modulation in cancer and metabolic disease
- Design of selective nuclear receptor modulators: RAR and RXR as a case study
- Feijoa sellowiana derived natural Flavone exerts anti-cancer action displaying HDAC inhibitory activities
- Structure, function and modulation of retinoic acid receptor beta, a tumor suppressor
- Electrocyclic ring opening of cis-bicyclo[m.n.0]alkenes: the anti-Woodward-Hoffmann quest
- A density functional theory study of the stille cross-coupling via associative transmetalation. The role of ligands and coordinating solvents
- Pseudopericyclic design drives antara-antara [1,5] methylene sigmatropic shifts from a stepwise to a concerted mechanism
- Bimetallic Intermediates in the Formation of Nucleophilic Allenylzincs from Allenylpalladiums: A DFT Study
- Bispyridinium Dienes: Histone Deacetylase Inhibitors with Selective Activities
- Cyclopent-2-en-1-one derivatives as PPAR modulators, their preparation, pharmaceutical and cosmetic compositions, and uses thereof
- Sulfoxide-Induced Stereoselection in [1,5]-Sigmatropic Hydrogen Shifts of Vinylallenes. A Computational Study
- Total synthesis of peridinin and related C37-norcarotenoid butenolides
- Preparation of cyclopent-2-en-1-one derivatives as PPAR modulators and their use in cosmetic and pharmaceutical compositions
- Specificity of Zebrafish Retinol Saturase: Formation of All-trans-13,14-dihydroretinol and All-trans-7,8-dihydroretinol
2006
- International union of pharmacology. LXIII. Retinoid X receptors
- International union of pharmacology. LX. Retinoic acid receptors
- Insights into the mechanism of the site-selective sequential palladium-catalyzed cross-coupling reactions of dibromothiophenes/dibromothiazoles and arylboronic acids. Synthesis of PPARb /d agonists
- The role of the 11-cis-retinal ring methyl substituents in visual pigment formation
- A methyl group at C7 of 11-cis-retinal allows chromophore formation but affects rhodopsin activation
- Activity of alcohol dehydrogenase with 11-cis-retinoids and distribution of ADH4 in ocular tissues
- The Stille Reaction in the Synthesis of the C37-Norcarotenoid Butenolide Pyrrhoxanthin. Scope and Limitations
- Cycloisomerization of Activated (2E,4Z)-Heptatrienoate and Its Relevance to Crispatene (Bio)synthesis. A Case of Concerted and Stepwise Uncertainty
- Computational Study and Analysis of the Kinetic Isotope Effects of the Rearrangement of cis-Bicyclo[4.2.0]oct-7-ene to cis,cis-Cycloocta-1,3-diene
- Natural and synthetic retinoids: structural bases and biological effects of potential clinical relevance for the prevention and treatment of infection-driven tumors
- Mechanism of the Gold(I)-Catalyzed Rautenstrauch Rearrangement: A Center-to-Helix-to-Center Chirality Transfer
- Computation of vertical excitation energies of retinal and analogs: Scope and limitations
- Synthesis of enantiopure C3- and C4-hydroxyretinals and their enzymatic reduction by ADH8 from Xenopus laevis
- Computational Characterization of a Complete Palladium-Catalyzed Cross-Coupling Process: The Associative Transmetalation in the Stille Reaction
- Synthesis of the PPARβ/δ-selective agonist GW501516 and C4-thiazole-substituted analogs
2005
- Mechanistic subtleties in the cyclopentannelation of allenolate allyl carbamates: the origin of the center-to-center chirality transfer
- Synthesis of N-heteroaryl Retinoids and Their Artificial Bacteriorhodopsins
- Ligand Recognition by RAR and RXR Receptors: Binding and Selectivity
- 2-Alkylidenesulfol-3-enes by (Regio and) Stereoselective Cheletropic Addition of SO2 to (Di)vinylallenes
- Simple Diastereoselectivity of the BF3·OEt2-Catalyzed Vinylogous Mukaiyama Aldol Reaction of 2-(Trimethylsiloxy)furans with Aldehydes
- Design and Synthesis of RXR Modulators
- 14-Fluoro-Bacteriorhodopsin Gelation Films for Dynamic Holography Recording
- Tumor-selective action of HDAC Inhibitors involves TRAIL induction in acute myeloid leukemia cells
- Effect of Dehydration on Photoinduced Transformation in Gelatin Films Made of WT and D96N 14-Fluoro-bacteriorhodopsin
- The Stille Reaction in the Synthesis of Carotenoid Butenolides: Synthesis of 6'-epi-Peridinin
- γ-Allenyl Allyl Benzothiazole Sulfonyl Anions Undergo cis-Selective (Sylvestre) Julia Olefinations
- Characterization of the Interaction between Retinoic Acid Receptor/Retinoid X Receptor (RAR/RXR) Heterodimers and Transcriptional Coactivators through Structural and Fluorescence Anisotropy Studies
- Ellipticity: A Convenient Tool to Characterize Electrocyclic Reactions
- Pseudorotation Barriers of Biological Oxyphosphoranes: A Challenge for Simulations of Ribozyme Catalysis
2004
- The Specicifity of Alcohol Dehydrogenase With cis-Retinoids
- 14-Fluorobacteriorhodopsin gelatin films: performance at different relative humidities
- Enantioselective Synthesis of all of the Stereoisomers of (E)-13,14-Dihydroxyretinol (DHR)
- Conrotatory Ring Opening Reactions of Cyclopropyl Anions in Monocyclic and Tricyclic Systems
- The Woodward-Hoffmann-DePuy rule revisited
- Pseudorotation of natural and chemically modified biological phosphoranes: implications for RNA catalysis
- Theoretical Study of the Vinyl Allene Oxide to Cyclopent-2-en-1-one Rearrangement: Mechanism, Torquoselectivity and Solvent Effects
- Theoretical Study of the Electrocyclic Ring Closure of Hydroxypentadienyl Cations
- Rational design of RAR selective agonists revealed by RAR-β crystal structure
- Kinetics of human alcohol dehydrogenase with ring-oxidized retinoids: effect of Tween 80
- 9-cis Retinoic Acid Analogues With Bulky Hydrophobic Rings: New RXR-Selective Agonists
- Synthesis of Ring-oxidized Retinoids as Substrates of Mouse Class I Alcohol Dehydrogenase (ADH1)
- Solvolytic Ring Opening Reactions of Cyclopropyl Halides. An Assessment of the Woodward-Hoffmann-DePuy Rule
2003
- Recent Advances in the Synthesis of Retinoids
- 9Z- and 11Z-8-Methylretinals for Artificial Visual Pigment Studies. Stereoselective Synthesis, Structure and Binding Modeling
2002
- Synthesis and Characterization of a New RXR Agonist Based on the 6-tert-Butyl-1,1-dimethylindanyl Structure
- Stereoselective Synthesis of Annular 9-cis-Retinoids and Binding Characterization to the Retinoid X Receptor
- Synthesis of Symmetrical Carotenoids by a Two-fold Stille Coupling
- Reply to: Electrocyclization of (Z)-1,2,4,6-Heptatetraene and Its Heterosubstituted Analogs: Pericyclic or Pseudopericyclic?
- Bleaching kinetics of artificial visual pigments with modifications near the ring/polyene chain connection
2001
- Photoinduced Transformation of 14-F-Bacteriorhodopsin Gelatin Films Based on Both Wild Type and D96N Mutants
- An Expedient Stereocontrolled Synthesis of 7-cis-Retinoids
- On the Aromatic Character of Electrocyclic and Pseudopericyclic Reactions: Thermal Cyclization of (2Z)-Hexa-2,4,5-trienals and their Schiff Bases
- A General Synthesis of Alkylpyridines
- Regioselective palladium-catalyzed cross-coupling reactions in the synthesis of novel 2,3-disubstituted thiophene derivatives
- Suzuki cross-coupling of meso-dibromoporphyrins for the synthesis of functionalized A2B2 porphyrins
- The Suzuki Coupling Reaction in the Stereocontrolled Synthesis of 9-cis-Retinoic Acid and Its Ring-Demethylated Analogues
2000
- A Pericyclic Cascade to the Stereocontrolled Synthesis of 9-cis-Retinoids
- Measurement of Proton Release and Uptake by Analogs of Bacteriorhodopsin
- Torquoselectivity in the Cationic Cyclopentannelation of (2Z)-Hexa-2,4,5-trienal Acetals
- Stereocontrolled Synthesis of 6-s-cis- and 6-s-trans-Locked 9Z-Retinoids by Hydroxyl-Accelerated Stille Coupling of (Z)-Tri-n-Butylstannylbut-2-en-1-ol and Bicyclic Dienyl Triflates
- Isomerization of all-trans-Retinol to cis-Retinols in Bovine Retinal Pigment Epithelial Cells: Dependence on the Specificity of Retinoid-Binding Proteins