2009

1. Retinoic acid and Wnt/β-catenin have complementary roles in anterior/posterior patterning embryos of the basal chordate amphioxus
   Takayuki Onai, Hsiu-Chin Lin, Michael Schubert, Demian Koop, Peter W. Osborne, Susana Alvarez, Rosana Alvarez, Nicholas D. Holland and Linda Z. Holland
   • Developmental Biology, 2009, Volume 332, Issue 2, Pages 223-233
2. Selective, potent PPARγ agonists with cyclopentenone core structure
   M. Paz Otero, Efrén Pérez Santín, Fátima Rodríguez-Barrios, Belén Vaz and Angel R. de Lera
   • Bioorg. Med. Chem. Lett.,2009, 19, 1883–1886
3. Activation of retinoic acid receptors by dihydroretinoids
   Alexander R. Moise, Susana Alvarez, Marta Domínguez, Rosana Alvarez, Marcin Golczak, Glenn P. Lobo, Johannes von Lintig, Angel R. de Lera, and Krzysztof Palczewski
   • Molecular Pharmacol. 2009 76(6) 1228-1237
4. C3 Halogen and C8’’ Substituents on Stilbene Arotinoids Modulate Retinoic Acid Receptor Subtype Function
   Susana Alvarez, Harshal Khanwalkar, Rosana Alvarez, Cathie Erb, Claudio Martínez, Fátima Rodríguez-Barrios, Pierre Germain, Hinrich Gronemeyer, and Angel R. de Lera
   • ChemMedChem 2009, 4, 1630 – 1640
5. Total synthesis of the natural isoprenylcysteine carboxyl methyltransferase inhibitor spermatinamine
   José García, Raquel Pereira, Angel R. de Lera
   • Tetrahedron Letters 2009, 50, 5028–5030
6. Stereocontrolled and Versatile Total Synthesis of Bispyrrolidinoindoline Diketopiperazine Alkaloids: Structural Revision of the Fungal Isolate (+)-Asperdimin
   Carlos Pérez-Balado, Paula Rodríguez-Graña, and Angel R. de Lera
   • Chem. Eur. J. 2009, 15, 9928 – 9937
7. Growth Factor-Antagonized Rexinoid Apoptosis Involves Permissive PPARg/RXR Heterodimers to Activate the Intrinsic Death Pathway by NO
   Pattabhiraman Shankaranarayanan, Aurélie Rossin, Harshal Khanwalkar, Susana Alvarez, Rosana Alvarez, Annica Jacobson, Angela Nebbioso, Angel R. de Lera, Lucia Altucci, and Hinrich Gronemeyer
   • Cancer Cell 2009, 16, 220–231
8. Modulating Retinoid X Receptor with a Series of (E)-3-[4-Hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic Acids and Their 4-Alkoxy Isomers
   Efrén Pérez Santín, Pierre Germain, Fabien Quillard, Harshal Khanwalkar, Fátima Rodríguez-Barrios, Hinrich Gronemeyer, Ángel R. de Lera and William Bourguet
   • J. Med. Chem. 2009, 52(10), 3150–3158
9. Retinoid Receptor Subtype-Selective Modulators Through Synthetic Modifications of RARγ Agonists
   Susana Álvarez, Rosana Álvarez, Harshal Khanwalkar, Pierre Germain, Géraldine Lemaire, Fátima Rodríguez-Barrios, Hinrich Gronemeyer, Ángel R. de Lera
   • Bioorganic & Medicinal Chemistry, 2009, 17(13), 4345-4359
10. Highly Potent Naphthofuran-Based Retinoic Acid Receptor Agonists
    Efrén Pérez Santín, Harshal Khanwalkar, Johannes Voegel, Pascal Collette, Pascale Mauvais, Hinrich Gronemeyer, Ángel R. de Lera
    • ChemMedChem, 2009, 4(5), 780-791
11. Pyrazine Arotinoids with Inverse Agonist Activities on the Retinoid and Rexinoid Receptors
    José García, Harshal Khanwalkar, Raquel Pereira, Cathie Erb, Johannes J. Voegel, Pascal Collette, Pascale Mauvais, William Bourguet, Hinrich Gronemeyer, Ángel R. de Lera
    • ChemBioChem, 2009, 10(7), 1252-1259
12. Regulation of Hoxb4 induction after neurulation by somite signal and neural competence
    Gayana S Amirthalingam, Sara Howard, Susana Alvarez, Angel R de Lera, and Nobue Itasaki
    • BMC Dev Biol. 2009; 9: 17
13. Regio-, Peri-, and Torquoselectivity in Hydroxy Heptatrienyl Cation Electrocyclizations: The Iso/Homo-Nazarov Reaction
    Olalla Nieto Faza, Carlos Silva López, Rosana álvarez, and ángel R. de Lera
    • Chem. Eur. J. 2009, 15(8), 1944 - 1956
14. The C-C Reductive Elimination in Palladium Complexes, and the Role of Coupling Additives. A DFT Study Supported by Experiment
    Martín Pérez-Rodríguez, Ataualpa A. C. Braga, Max Garcia-Melchor, Mónica H. Pérez-Temprano, Juan A. Casares,Gregori Ujaque, Angel R. de Lera,Rosana álvarez, Feliu Maseras and Pablo Espinet
    • J. Am. Chem. Soc. 2009, 131(10), 3650-3657
15. Palladium-Catalyzed Sequential Oxidative Cyclization/Coupling of 2-Alkynylphenols and Alkenes: A Direct Entry into 3-Alkenylbenzofurans"
    Martínez, Claudio; Aurrecoechea, José; álvarez, Rosana
    • Org Lett 2009, 11 (5), pp 1083–1086
16. ldo-keto reductases from the AKR1B subfamily: Retinoid specificity and control of cellular retinoic acid levels
    Xavier Ruiz; Oriol Gallego.; Albert Ardèvol.; Armando Moro.; Marta Domínguez.; Susana Alvarez.; Rosana Alvarez.; Angel R de Lera.; Carme Rovira.; Ignacio Fita.; Xavier Parés.; Jaume Farrés
    • Chemico-Biological Interactions 2009, 178(1-3) 171–177
17. Structural Coupling of 11-cis-7-Methyl-retinal and Amino Acids at the Ligand Binding Pocket of Rhodopsin
    Mònica Aguilà, Darwin Toledo, Margarita Morillo, Marta Dominguez, Belén Vaz, Rosana Alvarez, Angel R. de Lera, Pere Garriga
    • Photochemistry and Photobiology 2009, 85(2) March/April, 485-493
18. Highly Twisted Adamantyl Arotinoids: Synthesis, Antiproliferative Effects and RXR Transactivation Profiles
    Santiago Pérez-Rodríguez, Maria A. Ortiz, Raquel Pereira, Fátima Rodríguez-Barrios, Angel R. de Lera and F. Javier Piedrafita
    • European Journal of Medicinal Chemistry, 2009, 44 (6), 2434-2446
19. Isomer-specific effects of conjugated linoleic acid on gene expression in RAW 264.7
    Yunkyoung Lee, Jerry T. Thompson, Angel R. de Lera and John P. Vanden Heuvel
    • J. Nutrit. Biochem., 2009, Volume 20 Issue 11, Pages 848-59, 859.e1-5
20. Torquoselectivity in the electrocyclic ring-opening of cyclopropyl anions
    Faza, O.N., Silva López, C., González-Pérez, A.B., Pérez-Rodríguez, M., De Lera, A.R.
    • Journal of Physical Organic Chemistry, 2009, 22, 378-385
21. Mechanism of the gold-catalyzed rearrangement of (3-acyloxyprop-1-ynyl) oxiranes: A dual role of the catalyst
    Pérez, A.G., Silva López, C., Marco-Contelles, J., Faza, O.N., Soriano, E., De Lera, A.R.
    • Journal of Organic Chemistry, 2009, 74, 2982-2991
22. Electrocyclic ring opening of charged cis-bicyclo[3.2.0]heptadiene and heterocyclic derivatives. the anti-Woodward-Hoffmann quest (II)
    Silva López, C., Faza, O.N., De Lera, A.R.
    • Journal of Organic Chemistry, 2009, 74, 2396-2402
23. Complex thermal behavior of 11-cis-retinal, the ligand of the visual pigments
    Silva López, C., Alvarez, R., Domínguez, M., Faza, O.N., De Lera, A.R.
    • Journal of Organic Chemistry, 2009, 74, 1007-1013