Publications

2019

  1. Computational studies on the formation of aza-​oxypentadienyl intermediates from alkylidene oxaziridines and keteneimine oxides and their conversion to 1,​5-​dihydropyrrolones
    Pedro Villar, Lucía Guillade, Adán B. González-Pérez, Angel R. de Lera
  2. A Computational Study of Model Parent Systems and Reported Aza‐(Iso)Nazarov/Aza‐(Iso)Piancatelli Electrocyclic Reactions
    Adán B. González‐Pérez, Pedro Villar, Angel R. de Lera
  3. Alternative retinoid X receptor (RXR) ligands
    Wojciech Krężel, Ralph Rühl, Angel R.de Lera
  4. Deciphering the Origin of Enantioselectivity on the Cis-​Cyclopropanation of Styrene with Enantiopure Di-​chloro,​Di-​gold(I)​-​SEGPHOS Carbenoids Generated from Propargylic Esters
    Pedro Villar, Adán B. González-Pérez, Angel R. de Lera

2018

  1. Synthesis and Biological Evaluation of Tripartin, a Putative KDM4 Natural Product Inhibitor, and 1‐Dichloromethylinden‐1‐ol Analogues
    Lucía Guillade, Federica Sarno, Hanna Tarhonskaya, Angela Nebbioso, Susana Alvarez, Akane Kawamura, Prof. Christopher J. Schofield, Prof. Lucia Altucci, Prof. Dr. Ángel R. de Lera
  2. Precursor compounds for providing retinoids of the vitamin A5 pathway and uses thereof
    Wojciech Krezel, Ralph Rühl, Ángel R. de Lera
  3. Regioselective Palladium-Catalyzed Heterocyclization–Sonogashira Coupling Cascades from 2-Alkynylbenzamides and Terminal Alkynes: Experimental and DFT Studies
    Francisco Cruz, Belén Vaz, Unai Vilar, Aitor Ortega, Youssef Madich, Rosana Álvarez and José M. Aurrecoechea
  4. Synthesis of apocarotenoids by acyclic cross metathesis and characterization as substrates for human retinaldehyde dehydrogenases
    Marta Domínguez, Raquel Pequerul, Rosana Álvarez, Joan Giménez-Dejoz, Eszter Birta, Sergio Porté, Ralph Rühl, Xavier Parés, Jaume Farrés, Ángel R. de Lera

2017

  1. Mass Spectrometry of Algal Chlorophyll c Compounds
    Antonio Gavalas-Olea, Jose L. Garrido, Pilar Riobo, Susana Alvarez and Belen Vaz.
  2. Indole–Indole Ullmann Cross‐Coupling for CAr–N Bond Formation: Total Synthesis of (–)‐Aspergilazine A
    Iago Alonso, Rosana Alvarez and Ángel R. de Lera
  3. Synthesis of the octahydronaphthalene core of nahuoic acid A via a B(C6F5)3-catalyzed intramolecular Diels–Alder (IMDA) reaction
    Lucía Guillade, Adán B. González-Pérez and Ángel R. de Lera
  4. On the regiochemical differences between Pd-catalyzed heterocyclization–allylation and –arylation reactions of alkynylbenzamides: preparation of 4-allyl-isochromen-1-imines and computational study
    Rosana Álvarez, Unai Vilar, Youssef Madich and José M. Aurrecoechea
  5. Speciation of ZnMe2, ZnMeCl, and ZnCl2 in Tetrahydrofuran (THF), and Its Influence on Mechanism Calculations of Catalytic Processes
    Juan del Pozo, María Pérez-Iglesias, Rosana Álvarez, Agustí Lledós, Juan A. Casares, and Pablo Espinet
  6. Natural and structure-based RXR ligand scaffolds and their functions
    Marta Domínguez, Susana Alvarez, Angel R de Lera
  7. Structural basis for the inhibition of AKR1B10 by the C3 brominated TTNPB derivative UVI2008
    Francesc X Ruiz, Isidro Crespo, Susana Álvarez, Sergio Porté, Joan Giménez-Dejoz, Alexandra Cousido-Siah, André Mitschler, Ángel R de Lera, Xavier Parés, Alberto Podjarny, Jaume Farrés
  8. Lineage-specific duplication of amphioxus retinoic acid degrading enzymes (CYP26) resulted in sub-functionalization of patterning and homeostatic roles
    João E Carvalho, Maria Theodosiou, Jie Chen, Pascale Chevret, Susana Alvarez, Angel R De Lera, Vincent Laudet, Jenifer C Croce, Michael Schubert
  9. Rearrangement of vinyl allene oxide geometric isomers to cyclopentenones. Further computational insights with biologically relevant model systems
    Adán B. González-Pérez, Alexander Grechkinb and Ángel R. de Lera
  10. Reduced adiponectin expression after high-fat diet is associated with selective up-regulation of ALDH1A1 and further retinoic acid receptor signaling in adipose tissue
    Landrier J.F., Kasiri E., Karkeni E., Mihaly J., Beke G., Weiss K., Aydemir G., Salles J., Walrand S., de Lera A.R., Rühl R
  11. Total synthesis of naturally occurring (+)-psychotriasine and the related tetrahydro-β-carboline, dimeric tryptamines with N–C connectivities
    Samuel Gallego, Paula Lorenzo, Rosana Álvarez and Ángel R. de Lera

2016

  1. Epigenetic polypharmacology: from combination therapy to multitargeted drugs
    A.R. de Lera; A. Ganesan
  2. Relationship between All-trans-13,14-Dihydro Retinoic Acid and Pancreatic Adenocarcinoma
    A.V. Bazhin; T. Bleul; A.R. De Lera; J. Werner; R. Rühl
  3. An Endogenous Mammalian Retinoid X Receptor Ligand, at Last!
    Á.R. De Lera; W. Krezel; R. Rühl
  4. The Negishi Catalysis: Full Study of the Complications in the Transmetalation Step and Consequences for the Coupling Products
    Juan del Pozo, Gorka Salas, Rosana Álvarez, Juan A. Casares, and Pablo Espinet
  5. 19,19'-Diacyloxy Signature: An Atypical Level of Structural Evolution in Carotenoid Pigments
    Antonio Gavalás-Olea, Susana Alvarez, Pilar Riobó, Francisco Rodríguez, José L. Garrido, and Belén Vaz
  6. Stereocontrolled synthesis of (S)-9-cis- and (S)-11-cis-13,14-dihydroretinoic acid
    Belén Vaz, Rosana Alvarez, Angel R. de Lera
  7. Friedel–Crafts Alkylation of Indoles with p-Quinols: The Role of Hydrogen Bonding of Water for the Desymmetrization of the Cyclohexadienone System
    Carolina García-García, Laura Ortiz-Rojano, Susana Alvarez, Rosana Alvarez, María Ribagorda,and M. Carmen Carreño
  8. Evolutionary diversification of retinoic acid receptor (RAR) ligand-binding pocket structure by molecular tinkering
    Juliana Gutierrez-Mazariegos, Eswar Kumar Nadendla, Romain A. Studer, Susana Alvarez, Angel R. de Lera, Shigehiro Kuraku, William Bourguet, Michael Schubert, Vincent Laudet
  9. Exploiting the Multidentate Nature of Chiral Disulfonimides in a Multicomponent Reaction for the Asymmetric Synthesis of Pyrrolo[1,2-a]indoles: A Remarkable Case of Enantioinversion
    Dr. Alicia Galván, Dr. Adán B. González-Pérez, Prof. Dr. Rosana Álvarez, Prof. Dr. Angel R. de Lera, Prof. Dr. Francisco J. Fañanás, and Prof. Félix Rodríguez
  10. TSLP expression in the skin is mediated via RAR?-RXR pathways
    Mihaly J., Gericke J., Lucas R., de Lera, A.R., Alvarez S., Törocsik D., Rühl R

2015

  1. Stereoselective [3+2]-Carbocyclization of Indole Derived Imines and Electron-Rich Alkenes: A Divergent Synthesis of Cyclopenta[b]indole or Tetrahydroquinoline Derivatives
    Alicia Galván, Jonás Calleja, Adán B. González-Pérez, Rosana Álvarez, Angel R. de Lera, Francisco J. Fañanás and Félix Rodríguez
  2. Structural determinants of the selectivity of 3-benzyluracil-1-acetic acids towards human enzymes aldose reductase and AKR1B10
    Ruiz, Francesc; Cousido-Siah, Alexandra; Porte, Sergio; Dominguez, Marta; Crespo, Isidro; Rechlin, Chris; Mitschler, Andre; de Lera, Angel; Martín, Maria; de la Fuente, Jesus; Klebe, Gerhard; Pares, Xavier; Farres, Jaume; Podjarny, Alberto
  3. Modulation of Retinoic Acid Receptor Subtypes by 5- and 8-Substituted (Naphthalen-2-yl)-based Arotinoids
    Susana Alvarez, Michele Lieb, Claudio Martínez, Harshal Khanwalkar, Fátima Rodríguez-Barrios, Rosana Alvarez, Hinrich Gronemeyer, Angel R. de Lera
  4. 9-cis-13,14-dihydroretinoic acid is an endogenous retinoid acting as RXR ligand in mice
    Ralph Rühl, Agnieszka Krzyzosiak, Anna Niewiadomska-Cimicka, Natacha Rochel, Lajos Szeles, Belen Vaz, Marta Wietrzych-Schindler, Susana Alvarez, Monika Szklenar, Laszlo Nagy, Angel R. de Lera, Wojciech Krezel
  5. Evolution of the Role of RA and FGF Signals in the Control of Somitogenesis in Chordates
    Stéphanie Bertrand, Daniel Aldea, Silvan Oulion, Angel R. de Lera, Marie-Line Escande, Ildiko Somorjai, Hector Escriva
  6. Palladium-Catalyzed 6-endo-Selective Oxycyclization–Alkene Addition Cascades of ortho-Alkynylarylcarboxamides and alpha,beta-Unsaturated Carbonyl Compounds
    Youssef Madich, Rosana Álvarez, and José M. Aurrecoechea
  7. Organometallic Nucleophiles and Pd: What Makes ZnMe2 Different? Is Au Like Zn?
    Juan delPozo, Estefanía Gioria, Juan A. Casares, Rosana Álvarez, and Pablo Espinet
  8. Synthesis of labile all-trans-7,8,7’,8’-bis-acetylenic carotenoids by bidirectional Horner-Wadsworth-Emmons condensation
    Belén Vaz, Noelia Fontán, Marta Castiñeira, Rosana Álvarez, and Ángel R. de Lera
  9. Synthesis of 7-Alkylidene-7,12-dihydroindolo[3,2-d]benzazepine-6-(5H)-ones (7-Alkylidene-Paullones) by N-cyclization-Oxidative Heck Cascade and Characterization as Sirtuin Modulators
    J. G. Denis, G. Franci, L. Altucci, J. M. Aurrecoechea, A. R. de Lera, and R. Álvarez
  10. Palladium Nanoparticle-Loaded Cellulose Paper: A Highly Efficient, Robust, and Recyclable Self-Assembled Composite Catalytic System
    Guangchao Zheng, Katharina Kaefer, Stefanos Mourdikoudis, Lakshminarayana Polavarapu, Belén Vaz, Samantha E. Cartmell, Azzedine Bouleghlimat, Niklaas J. Buurma, Luis Yate, Ángel R. de Lera, Luis M. Liz-Marzán, Isabel Pastoriza-Santos, and Jorge Pérez-Juste

2014

  1. Roles of retinoic acid and Tbx1/10 in pharyngeal segmentation: amphioxus and the ancestral chordate condition
    Demian Koop, Jie Chen, Maria Theodosiou, João E Carvalho, Susana Alvarez, Angel R de Lera, Linda Z Holland, and Michael Schubert
  2. Silicon particles as trojan horses for potential cancer therapy
    Roberto Fenollosa, Eduardo Garcia-Rico, Susana Alvarez, Rosana Alvarez, Xiang Yu, Isabel Rodriguez, Susana Carregal-Romero, Carlos Villanueva, Manuel Garcia-Algar, Pilar Rivera-Gil, Angel R de Lera, Wolfgang J Parak, Francisco Meseguer and Ramón A Alvarez-Puebla
  3. A unifying mechanism for the rearrangement of vinyl allene oxide geometric isomers to cyclopentenones
    Adán B. González-Pérez, Alexander Grechkin and Ángel R. de Lera
  4. Palladium-Catalyzed Regioselective 5-exo-O-Cyclization/Oxidative Heck Cascades from o-Alkynylbenzamides and Electron-Deficient Alkenes
    Youssef Madich, Rosana Álvarez and José M. Aurrecoechea
  5. Dual RXR Agonists and RAR Antagonists Based on the Stilbene Retinoid Scafold
    Claudio Martínez, Michele Lieb, Susana Alvarez, Fátima Rodríguez-Barrios, Rosana Alvarez, Harshal Khanwalkar, Hinrich Gronemeyer, and Angel R. de Lera
  6. Total Synthesis and Structural Revision of (–)-Protubonine A and (–)-Protubonine B
    Paula Lorenzo, Rosana Alvarez, and Angel R. de Lera
  7. Total Synthesis and Structural Revision of (+)-Cristatumin C
    Paula Lorenzo, Rosana Alvarez, and Angel R. de Lera
  8. Enantioselective Synthesis of Hexahydrofuro[3,2-c]quinolines through a Multicatalytic and Multicomponent Process. A New “Aromatic Sandwich” Model for BINOL-Phosphoric Acid Catalyzed Reactions
    Jonás Calleja, Adán B Gónzalez Pérez, Angel R. de Lera, Rosana Alvarez, Francisco Fañanas, and Félix Rodríguez
  9. Identification of a novel polyfluorinated compound as a lead to inhibit human enzymes aldose reductase and AKR1B10: structure determination of both ternary complexes and implications for drug design
    A. Cousido-Siah, F. X. Ruiz, A. Mitschler, S. Porté, Á. R. de Lera, M. J. Martín, S. Manzanaro, J. A. de la Fuente, F. Terwesten, M. Betz, G. Klebe, J. Farrés, X. Parés and A. Podjarny
  10. Functions, Therapeutic Applications, and Synthesis of Retinoids and Carotenoids
    Rosana Álvarez, Belén Vaz, Hinrich Gronemeyer and Ángel R. de Lera

2013

  1. A Practical Protocol for Three-Component One-Pot Stepwise Sonogashira-Heterocyclization/Heck-Couplings
    Youssef Madich, J. Gabriel Denis, Aitor Ortega, Claudio Martínez, Abdellatif Matrane, Majid Belachemi, Angel R. de Lera, Rosana Alvarez, José M. Aurrecoechea
  2. Catalyst- and Solvent-Dependent Stereodivergence in the Intramolecular Et2Zn/Pd0-Promoted Carbonyl Propargylation: Mechanistic Implications
    Mónica Arrate, Aritz Durana, Paula Lorenzo, Ángel R. de Lera, Rosana Álvarez, and José M. Aurrecoechea
  3. Total Synthesis of Enantiopure Pyrrhoxanthin: Alternative Methods for the Stereoselective Preparation of 4-Alkylidenebutenolides
    Belén Vaz, Leticia Otero, Rosana Álvarez, Ángel R. de Lera
  4. Adamantyl Arotinoids That Inhibit IκB Kinase α and IκB Kinase β
    Paula Lorenzo, María A. Ortiz, Rosana Alvarez, F. Javier Piedrafita, and Angel R. de Lera
  5. Macroscale Plasmonic Substrates for Highly Sensitive Surface-Enhanced Raman Scattering
    María Alba, Nicolas Pazos-Perez, Belén Vaz, Pilar Formentin, Moritz Tebbe, Miguel A. Correa-Duarte, Pedro Granero, Josep Ferré-Borrull, Rosana Alvarez, Josep Pallares, Andreas Fery, Angel R. de Lera, Lluis F. Marsal, and Ramón A. Alvarez-Puebla
  6. Regulation of Retinoid-Mediated Signaling Involved in Skin Homeostasis by RAR and RXR Agonists/Antagonists in Mouse Skin
    Janine Gericke, Jan Ittensohn, Johanna Mihály2, Susana A lvarez, Rosana Alvarez, Dániel Töröcsik, Angel R. de Lera, Ralph Rühl
  7. Total Synthesis of (8R,6'R)-Peridinin-5,8-Furanoxide
    Leticia Otero, Belén Vaz, Rosana Álvarez, and Ángel R. de Lera
  8. Aldo–keto reductases in retinoid metabolism: Search for substrate specificity and inhibitor selectivity
    Sergio Porté, F. Xavier Ruiz, Joan Giménez, Iago Molist, Susana Alvarez, Marta Domínguez, Rosana Alvarez, Angel R. de Lera, Xavier Parés, Jaume Farrés
  9. Palladium-Catalyzed Diorganozinc Conjugate Additions to Enones: Preparative and Computational Studies
    Paula Lorenzo, José M. Aurrecoechea, Angel R. de Lera, and Rosana Álvarez
  10. A conjunctive diiodoheptaene for the synthesis of C2-symmetric carotenoids
    Noelia Fontán, Belén Vaz, Rosana Alvarez and Angel R. de Lera
  11. Characterization of pericyclic steps in the mechanisms of Gold(I) catalyzed rearrangement of alkynes
    Adán González Pérez, Rosana Álvarez, Ángel R. de Lera
  12. Stille Coupling Involving Bulky Groups Feasible with Gold Cocatalyst
    Juan del Pozo, Desirée Carrasco, Mónica H. Pérez-Temprano, Max García-Melchor, Rosana Álvarez, Juan A. Casares, and Pablo Espinet
  13. Novel Symmetrical Ureas as Modulators of Protein Arginine Methyl Transferases
    Noelia Fontán, Patricia García-Domínguez, Rosana Álvarez, Ángel R. de Lera

2012

  1. A DNA Methyltransferase Modulator Inspired by Peyssonenyne Natural Product Structures
    Garcia-Dominguez, Patricia; Weiss, Melanie; Lepore, Ilaria; Alvarez, Rosana; Altucci, Lucia; Gronemeyer, Hinrich; de Lera, Angel R
  2. Indole-Derived Psammaplin A Analogues as Epigenetic Modulators with Multiple Inhibitory Activities
    Pereira, Raquel; Benedetti, Rosaria; Perez-Rodriguez, Santiago; Nebbioso, Angela; Garcia-Rodriguez, Jose; Carafa, Vincenzo; Stuhldreier, Mayra; Conte, Mariarosaria; Rodriguez-Barrios, Fatima; Stunnenberg, Hendrik G.; Gronemeyer, Hinrich; Altucci, Lucia; de Lera, Angel R
  3. Advances in drug design with RXR modulators
    Vaz, Belen; de Lera, Angel R
  4. Mechanistic and Sterochemical Insights on the Pt-Catalyzed Rearrangement of Oxiranylpropargylic Esters to Cyclopentenones
    Adán B. González-Pérez , Belén Vaz , Olalla Nieto Faza, and Ángel R. de Lera
  5. Probing a Polar Cluster in the Retinal Binding Pocket of Bacteriorhodopsin by a Chemical Design Approach
    Rosana Simón-Vázquez, Marta Domínguez, Víctor A. Lórenz-Fonfría, Susana Álvarez, José-Luís Bourdelande, Ángel R. de Lera, Esteve Padrós, Alex Perálvarez-Marín
  6. Retinoid Receptors and Therapeutic Applications of RAR/RXR Modulators
    Albane le Maire, Susana Alvarez, Pattabhiraman Shankaranarayanan, Angel R de Lera, William Bourguet, Hinrich Gronemeyer
  7. Survey of Synthetic Approaches to Natural (Peyssonenynes) and Unnatural Acetoxyenediynes
    Patricia García-Domínguez, Rosana Alvarez, Ángel R. de Lera
  8. First total synthesis of dioxepine bastadin 3
    Santiago Pérez-Rodríguez, Raquel Pereira-Cameselle and Ángel R. de Lera
  9. Retinoic Acid Receptors and their Modulators: Structural and Functional Insights
    Albane le Maire, Susana Alvarez, Pattabhiraman Shankaranarayanan, Angel R de Lera, William Bourguet, Hinrich Gronemeyer
  10. Stereoselective Synthesis by Olefin Metathesis and Characterization of n-Carotene (7,8,7',8'-tetrahydro-ß,ß-carotene)
    Fontán N, Álvarez R, de Lera AR
  11. Modulation of RXR function through ligand design
    Pérez E, Bourguet W, Gronemeyer H, de Lera AR
  12. Strong Metallophilic Interactions in the Palladium Arylation by Gold Aryls
    Pérez-Temprano MH, Casares JA, de Lera AR, Álvarez R, Espinet P
  13. Characterization of [8-ethyl]-chlorophyll c3 from Emiliania huxleyi
    Álvarez S, Zapata M, Garrido JL, Vaz B
  14. DFT-Based Insights into Pd -Zn Cooperative Effects in Oxidative Addition and Reductive Elimination Processes Relevant to Negishi Cross-Couplings
    González-Pérez AB, Álvarez R, Faza ON, Lera AR, Aurrecoechea JM
  15. New synthetic approach to paullones and characterization of their SIRT1 inhibitory activity
    Soto S, Vaz E, Dell’Aversana C, Álvarez R, Altucci L, de Lera AR
  16. Palladium-Catalyzed Intermolecular C(sp3)-H Amidation
    Iglesias A, Alvarez R, de Lera AR, Muñiz K
  17. Stereocontrolled synthesis of (S )-9- cis-4-oxo-13,14-dihydroretinoic acid
    Domínguez M, Alvarez S, Alvarez R, de Lera AR
  18. Synthesis of Tetrahydrodibenzofuran and Tetrahydrophenanthridinone Skeletons by Intramolecular Nucleopalladation/Oxidative Heck Cascades
    Martínez C,Aurrecoechea JM, Madich Y,Denis JG, de Lera AR, Álvarez R
  19. A general LbL strategy for the growth of pNIPAM microgels on Au nanoparticles with arbitrary shapes
    Fernández-López C,Pérez-Balado C, Pérez-Juste,Pastoriza-Santos, de Lera AR, Liz-Marzán LM

2011

  1. Death Receptor Pathway Activation and Increase of ROS Production by the Triple Epigenetic Inhibitor UVI5008
    Nebbioso A.; Pereira R, Khanwalkar H, Matarese F, Garcia-Rodriguez J, Miceli M, Logie C, Kedinger V, Ferrara F, Stunnenberg HG, de Lera AR, Gronemeyer H, Altucci L
  2. Epigenetic Multiple Modulators
    Álvarez R, Altucci L, Gronemeyer H, de Lera AR
  3. Synthesis of C40-Symmetrical Fully-Conjugated Carotenoids by Olefin Metathesis
    Fontán N, Domínguez M, Álvarez R, de Lera AR
  4. Residual Dipolar Coupling Enhanced NMR Spectroscopy and Chiroptics: A Powerful Combination for the Complete Elucidation of Symmetrical Small Molecules
    Pérez-Balado C, Sun H, Griesinger c, de Lera AR, Navarro-Vázquez A
  5. Total synthesis of the proposed structures of the DNA methyl transferase inhibitors peyssonenynes, and structural revision of peyssonenyne B
    García-Domínguez P, Lepore I, Erb C, Gronemeyer H, Altucci L, Álvarez R and de Lera AR.
    Organic & Biomolecular Chemistry 2011, 9 (20), 6979-6987
  6. DFT-Based Mechanistic Insights Into Noble Metal-Catalyzed Rearrangement of Propargylic Derivatives: Chirality Transfer Processes
    Nieto Faza O. and de Lera AR.
  7. Bond Ellipticity As a Measure of Electron Delocalization in Structure and Reactivity
    Silva López C. and de Lera AR.
  8. Epigenetic Profiling of the Antitumor Natural Product Psammaplin A and Its Analogues
    García-Rodríguez J, Franci G, Pereira R, Benedetti R, Nebbioso A, Rodríguez-Barrios F, Gronemeyer H, Altucci L, de Lera AR.
  9. Design and Stereoselective Synthesis of Retinoids with Ferrocene or N-Butylcarbazole Pharmacophores that Induce Post-Differentiation Apoptosis in Acute Promyelocytic Leukemia Cells
    Ivanova D, Gronemeyer H, de Lera AR
  10. Computational Study of the Intramolecular Pericyclic Reactions of Aldazines and Some Pseudopericyclic Variants
    González-Pérez AB, Souto JA, Silva-López C, de Lera AR
  11. Retinoid X Receptor Gamma Is Implicated in Docosahexaenoic Acid Modulation of Despair Behaviors and Working Memory in Mice
    Wietrzych-Schindler M, Szyszka-Niagolov M, Ohta K, Endo Y, Pérez E, de Lera AR, Chambon P, Krezel W
  12. Retinoid-Independent Motor Neurogenesis From Human Embryonic Stem Cells Reveals A Medial Columnar Ground State
  13. On the Memory of Chirality in Gold(I)-Catalyzed Intramolecular Carboalkoxylation of Alkynes
    Nieto-Faza O, Silva-Lopez C, de Lera A. R.
  14. Enantioselective Conjugate Addition of Nitro Compounds to alpha,beta-Unsaturated Ketones: An Experimental and Computational Study
    Manzano R, Andrés JM, Álvarez R, Muruzábal MD, de Lera AR, Pedrosa R.
  15. Separation of regioisomers and enantiomers of underivatized saturated and unsaturated fatty acid monoacylglycerols using enantioselective HPLC
    García P., Franco P, Alvarez R., de Lera A. R.
  16. Production of hemicellulosic sugars from Pinus pinaster wood by sequential steps of aqueous extraction and acid hydrolysis
    González-Muñoz JM, Alvarez R, Santos V, Parajó JC.
  17. Retinoic acid receptor modulators: a perspective on recent advances and promises
    Alvarez S, Bourguet W, Gronemeyer H, de Lera A. R.

2010

  1. Concise total synthesis and structural revision of (+)-pestalazine B
    Pérez-Balado C, de Lera A. R.
  2. Inverse agonists and antagonists of retinoid receptors
    Bourguet W, de Lera A.R., Gronemeyer H.
  3. A General Synthesis of Alkenyl-Substituted Benzofurans, Indoles, and Isoquinolones by Cascade Palladium-Catalyzed Heterocyclization/Oxidative Heck Coupling
    Rosana Alvarez, Claudio Martínez, Youssef Madich, J. Gabriel Denis,José M. Aurrecoechea, and Angel R. de Lera
  4. Nolz1 promotes striatal neurogenesis through the regulation of retinoic acid signaling
    Noelia Urbán, Raquel Martín-Ibáñez, Cristina Herránz, Miriam Esgleas, Empar Crespo, Mónica Pardo1, Iván Crespo-Enríquez, Héctor R Méndez-Gómez, Ronald Waclaw, Christina Chatzi, Susana Alvarez, Rosana Alvarez, Gregg Duester, Kenneth Campbell, Angel R de Lera, Carlos Vicario-Abejón, Salvador Martínez, Jordi Alberch, Josep M Canals
  5. New Anacardic Acid-Inspired Benzamides, Histone Lysine Acetyltransferase Activators
    José A. Souto, Rosaria Benedetti, Kattarina Otto, Marco Miceli, Rosana Alvarez, Lucia Altucci, and Angel R. de Lera
  6. Synthesis of Diverse Indole-Containing Scaffolds by Gold(I)-Catalyzed Tandem Reactions of 3-Propargylindoles Initiated by 1,2-Indole Migrations: Scope and Computational Studies
    Roberto Sanz, Delia Miguel, Mukut Gohain, Patricia García-García, Manuel A. Fernández-Rodríguez, Adán González-Pérez, Olalla Nieto-Faza, Angel R. de Lera, and Félix Rodríguez
    Corrigendum: Synthesis of Diverse Indole-Containing Scaffolds by Gold(I)-Catalyzed Tandem Reactions of 3-Propargylindoles Initiated by 1,2-Indole Migrations: Scope and Computational Studies Chem. Eur. J. 2011,17, 13117.
  7. Competing Thermal Electrocyclic Ring-Closure Reactions of (2Z)-Hexa-2,4,5-trienals and Their Schiff Bases. Structural, Kinetic, and Computational Studies
    José A. Souto, Martín Pérez, Carlos Silva López, Rosana Alvarez, Alicia Torrado and Angel R. de Lera
  8. A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor
    Albane le Maire, Catherine Teyssier, Cathie Erb, Marina Grimaldi, Susana Alvarez, Angel R de Lera, Patrick Balaguer, Hinrich Gronemeyer, Catherine A Royer, Pierre Germain and William Bourguet
  9. A DFT Study of the Effect of the Ligands in the Reductive Elimination from Palladium Bis(allyl) Complexes
    Martín Pérez-Rodríguez, Ataualpa A. C. Braga, Angel R. de Lera, Feliu Maseras, Rosana Alvarez, and Pablo Espinet
  10. Synthesis and Biological Characterization of the Histone Deacetylase Inhibitor Largazole and C7- Modified Analogues
    José A. Souto, Esther Vaz, Ilaria Lepore, Ann-Christin Poeppler, Gianluigi Franci, Rosana Alvarez, Lucia Altucci, and Angel R. de Lera
  11. Determination of the geometry of acetoxyendiynes and acetoxyenynes by NMR heteronuclear 13C–1H scalar couplings and 13C NMR chemical shifts. Structural assignment of the oxylipin natural products peyssonenynes A and B
    Patricia García, Manuel Martín-Pastor, Angel R. de Lera and Rosana Alvarez
  12. Retinoic acid signaling targets Hox genes during the amphioxus gastrula stage: insights into early anterior-posterior patterning of the chordate body plan
    Demian Koop, Nicholas D. Holland, Marie Sémon, Susana Alvarez, Angel R. de Lera, Vincent Laudet, Linda Z. Holland and Michael Schubert
  13. Understanding abnormal retinoid signaling as a causative mechanism in congenital diaphragmatic hernia
    Clugston, R. D.; Zhang, W.; Alvarez, S.; de Lera, A. R.; Greer J. J.
  14. Increased adiposity in the retinol saturase-knockout mouse
    Alexander R. Moise, Glen P. Lobo, Susana Alvarez, Marta Domínguez, Rosana Alvarez, Kris Flask, Angel R. de Lera, Johannes von Lintig, and Krzysztof Palczewski
  15. FTY720 Stimulates 27-Hydroxycholesterol Production and Confers Atheroprotective Effects in Human Primary Macrophages
    Tomas Blom, Nils Bäck, Aino-Liisa Mutka, Robert Bittman, Zaiguo Li, Angel de Lera, Petri T. Kovanen, Ulf Diczfalusy, Elina Ikonen

2009

  1. Retinoic acid and Wnt/β-catenin have complementary roles in anterior/posterior patterning embryos of the basal chordate amphioxus
    Takayuki Onai, Hsiu-Chin Lin, Michael Schubert, Demian Koop, Peter W. Osborne, Susana Alvarez, Rosana Alvarez, Nicholas D. Holland and Linda Z. Holland
  2. Selective, potent PPARγ agonists with cyclopentenone core structure
    M. Paz Otero, Efrén Pérez Santín, Fátima Rodríguez-Barrios, Belén Vaz and Angel R. de Lera
  3. Activation of retinoic acid receptors by dihydroretinoids
    Alexander R. Moise, Susana Alvarez, Marta Domínguez, Rosana Alvarez, Marcin Golczak, Glenn P. Lobo, Johannes von Lintig, Angel R. de Lera, and Krzysztof Palczewski
  4. C3 Halogen and C8’’ Substituents on Stilbene Arotinoids Modulate Retinoic Acid Receptor Subtype Function
    Susana Alvarez, Harshal Khanwalkar, Rosana Alvarez, Cathie Erb, Claudio Martínez, Fátima Rodríguez-Barrios, Pierre Germain, Hinrich Gronemeyer, and Angel R. de Lera
  5. Total synthesis of the natural isoprenylcysteine carboxyl methyltransferase inhibitor spermatinamine
    José García, Raquel Pereira, Angel R. de Lera
  6. Stereocontrolled and Versatile Total Synthesis of Bispyrrolidinoindoline Diketopiperazine Alkaloids: Structural Revision of the Fungal Isolate (+)-Asperdimin
    Carlos Pérez-Balado, Paula Rodríguez-Graña, and Angel R. de Lera
  7. Growth Factor-Antagonized Rexinoid Apoptosis Involves Permissive PPARg/RXR Heterodimers to Activate the Intrinsic Death Pathway by NO
    Pattabhiraman Shankaranarayanan, Aurélie Rossin, Harshal Khanwalkar, Susana Alvarez, Rosana Alvarez, Annica Jacobson, Angela Nebbioso, Angel R. de Lera, Lucia Altucci, and Hinrich Gronemeyer
  8. Modulating Retinoid X Receptor with a Series of (E)-3-[4-Hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic Acids and Their 4-Alkoxy Isomers
    Efrén Pérez Santín, Pierre Germain, Fabien Quillard, Harshal Khanwalkar, Fátima Rodríguez-Barrios, Hinrich Gronemeyer, Ángel R. de Lera and William Bourguet
  9. Retinoid Receptor Subtype-Selective Modulators Through Synthetic Modifications of RARγ Agonists
    Susana Álvarez, Rosana Álvarez, Harshal Khanwalkar, Pierre Germain, Géraldine Lemaire, Fátima Rodríguez-Barrios, Hinrich Gronemeyer, Ángel R. de Lera
  10. Highly Potent Naphthofuran-Based Retinoic Acid Receptor Agonists
    Efrén Pérez Santín, Harshal Khanwalkar, Johannes Voegel, Pascal Collette, Pascale Mauvais, Hinrich Gronemeyer, Ángel R. de Lera
  11. Pyrazine Arotinoids with Inverse Agonist Activities on the Retinoid and Rexinoid Receptors
    José García, Harshal Khanwalkar, Raquel Pereira, Cathie Erb, Johannes J. Voegel, Pascal Collette, Pascale Mauvais, William Bourguet, Hinrich Gronemeyer, Ángel R. de Lera
  12. Regulation of Hoxb4 induction after neurulation by somite signal and neural competence
    Gayana S Amirthalingam, Sara Howard, Susana Alvarez, Angel R de Lera, and Nobue Itasaki
  13. Regio-, Peri-, and Torquoselectivity in Hydroxy Heptatrienyl Cation Electrocyclizations: The Iso/Homo-Nazarov Reaction
    Olalla Nieto Faza, Carlos Silva López, Rosana álvarez, and ángel R. de Lera
  14. The C-C Reductive Elimination in Palladium Complexes, and the Role of Coupling Additives. A DFT Study Supported by Experiment
    Martín Pérez-Rodríguez, Ataualpa A. C. Braga, Max Garcia-Melchor, Mónica H. Pérez-Temprano, Juan A. Casares,Gregori Ujaque, Angel R. de Lera,Rosana álvarez, Feliu Maseras and Pablo Espinet
  15. Palladium-Catalyzed Sequential Oxidative Cyclization/Coupling of 2-Alkynylphenols and Alkenes: A Direct Entry into 3-Alkenylbenzofurans"
    Martínez, Claudio; Aurrecoechea, José; álvarez, Rosana
  16. ldo-keto reductases from the AKR1B subfamily: Retinoid specificity and control of cellular retinoic acid levels
    Xavier Ruiz; Oriol Gallego.; Albert Ardèvol.; Armando Moro.; Marta Domínguez.; Susana Alvarez.; Rosana Alvarez.; Angel R de Lera.; Carme Rovira.; Ignacio Fita.; Xavier Parés.; Jaume Farrés
  17. Structural Coupling of 11-cis-7-Methyl-retinal and Amino Acids at the Ligand Binding Pocket of Rhodopsin
    Mònica Aguilà, Darwin Toledo, Margarita Morillo, Marta Dominguez, Belén Vaz, Rosana Alvarez, Angel R. de Lera, Pere Garriga
  18. Highly Twisted Adamantyl Arotinoids: Synthesis, Antiproliferative Effects and RXR Transactivation Profiles
    Santiago Pérez-Rodríguez, Maria A. Ortiz, Raquel Pereira, Fátima Rodríguez-Barrios, Angel R. de Lera and F. Javier Piedrafita
  19. Isomer-specific effects of conjugated linoleic acid on gene expression in RAW 264.7
    Yunkyoung Lee, Jerry T. Thompson, Angel R. de Lera and John P. Vanden Heuvel
  20. Torquoselectivity in the electrocyclic ring-opening of cyclopropyl anions
    Faza, O.N., Silva López, C., González-Pérez, A.B., Pérez-Rodríguez, M., De Lera, A.R.
  21. Mechanism of the gold-catalyzed rearrangement of (3-acyloxyprop-1-ynyl) oxiranes: A dual role of the catalyst
    Pérez, A.G., Silva López, C., Marco-Contelles, J., Faza, O.N., Soriano, E., De Lera, A.R.
  22. Electrocyclic ring opening of charged cis-bicyclo[3.2.0]heptadiene and heterocyclic derivatives. the anti-Woodward-Hoffmann quest (II)
    Silva López, C., Faza, O.N., De Lera, A.R.
  23. Complex thermal behavior of 11-cis-retinal, the ligand of the visual pigments
    Silva López, C., Alvarez, R., Domínguez, M., Faza, O.N., De Lera, A.R.

2008

  1. Novel derivatives of psammaplin A, a method for their synthesis and their use for the prevention or treatment of cancer
    Gronemeyer, Hinrich; Altucci, Lucia; De Lera, Angel; Stunnenberg, Hendrik Gerard
  2. Derivatives of psammaplin A, a method for their synthesis and their use for the prevention or treatment of cancer
    Gronemeyer, Hinrich; De Lera, Angel; Altucci, Lucia
  3. Expedient Total Syntheses of WIN 64745 and WIN 64821
    Carlos Pérez-Balado and Angel R. de Lera
  4. New retinoid chemotypes: 9-cis-Retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists
    Susana Álvarez, Yolanda Pazos-Randulfe, Harshal Khanwalkar, Pierre Germain, Rosana Álvarez, Hinrich Gronemeyer, and ángel R. de Lera
  5. Stereoselective Stille Coupling of Enantiopure Haloallenes and Alkenylstannanes for the Synthesis of Allenyl Carotenoids. Experimental and Computational Studies
    Belén Vaz, Raquel Pereira, Martín Pérez, Rosana Álvarez, Angel R. de Lera
  6. Nuclear receptor ligand binding domains: reduction of helix H12 dynamics to favor crystallization
    Virginie Nahoum, Alexandra Lipski, Fabien Quillard, Jean-François Guichou, Yvan Boublik, Efrén Pérez, Pierre Germain, Angel R. de Lera, and William Bourguet
  7. Inhibition of IκB Kinaseβ and Anticancer Activities of Novel Chalcone Adamantyl Arotinoids
    Paula Lorenzo, Rosana Alvarez, Maria A. Ortiz, Susana Alvarez, F. Javier Piedrafita and Angel R. de Lera
  8. The Associative Transmetalation in the Stille Cross-Coupling Reaction to Form Dienes: Theoretical Insights into the Open Pathway
    Rosana Álvarez, Martín Pérez, Olalla Nieto Faza and Angel R. de Lera
  9. Synthesis of Benzamides Related to Anacardic Acid and Their Histone Acetyltransferase (HAT) Inhibitory Activities
    José A. Souto, Mariarosaria Conte, Rosana Álvarez, Angela Nebbioso, Vincenzo Carafa, Lucia Altucci, and Angel R. de Lera
  10. Photochromic polymer films based on a 14-F bacteriorhodopsin derivative
    Anna Druzhko, Rosana Álvarez and Angel R. de Lera
  11. Retinoic acid analogues inhibit Human Herpesvirus 8 replication
    Elisabetta Caselli, Galvan Monica, Fabio Santoni, Susana Alvarez, Angel R. de Lera, Diana Ivanova, Hinrich Gronemeyer, Arnaldo Caruso, Massimo Guidoboni, Enzo Cassai, Riccardo Dolcetti, and Dario Di Luca
  12. Stereospecificity of Retinol Saturase: Absolute Configuration, Synthesis and Biological Evaluation of Dihydroretinoids
    Alexander R. Moise, Marta Domínguez, Susana Alvarez, Rosana Alvarez, Michael Schupp, Ana G. Cristancho, Philip D. Kiser, Angel R. de Lera, Mitchell A. Lazar, Krzysztof Palczewski
  13. Characterization of the Switch in the Mechanism of an Intramolecular Diels-Alder Reaction
    Silva Lopez, Carlos; Nieto Faza, Olalla; de Lera, Angel R.
  14. Mechanistic Insights into the Stereocontrolled Synthesis of Hexahydropyrrolo[2,3-b]indoles by Electrophilic Activation of Tryptophan Derivatives
    Silva Lopez, Carlos; Perez-Balado, Carlos; Rodriguez-Grana, Paula; de Lera, Angel R.

2007

  1. Structural basis for the high all-trans retinaldehydr reductase activity of the tumor marker AKR1B10
    Oriol Gallego, F. Xavier Ruiz, Albert Ardèvol, Marta Domínguez, Rosana Alvarez, Angel R. de Lera, Carme Rovira, Jaume Farrés, Ignacio Fita and Xavier Parés
  2. Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function
    Nahoum, Virginie; Perez, Efren; Germain, Pierre; Rodriguez-Barrios, Fatima; Manzo, Fabio; Kammerer, Sabrina; Lemaire, Geraldine; Hirsch, Oliver; Royer, Catherine A.; Gronemeyer, Hinrich; de Lera, Angel R.; Bourguet, William
  3. Deuterium exchange and mass spectrometry reveal the interaction differences of two synthetic modulators of RXRa LBD
    Yan, Xuguang; Perez, Efren; Leid, Mark; Schimerlik, Michael I.; De Lera, Angel R.; Deinzer, Max L.
  4. Rapid, nongenomic actions of retinoic acid on phosphatidylinositol-3-kinase signaling pathway mediated by the retinoic acid receptor
    Masia, Susana; Alvarez, Susana; de Lera, Angel R.; Barettino, Domingo
  5. RAR and RXR modulation in cancer and metabolic disease
    Altucci, Lucia; Leibowitz, Mark D.; Ogilvie, Kathleen M.; de Lera, Angel R.; Gronemeyer, Hinrich
  6. Design of selective nuclear receptor modulators: RAR and RXR as a case study
    de Lera, Angel R.; Bourguet, William; Altucci, Lucia; Gronemeyer, Hinrich
  7. Feijoa sellowiana derived natural Flavone exerts anti-cancer action displaying HDAC inhibitory activities
    Bontempo, Paola; Mita, Luigi; Miceli, Marco; Doto, Antonella; Nebbioso, Angela; De Bellis, Floriana; Conte, Mariarosaria; Minichiello, Annunziata; Manzo, Fabio; Carafa, Vincenzo; Basile, Adriana; Rigano, Daniela; Sorbo, Sergio; Castaldo Cobianchi, Rosa; Schiavone, Ettore Mariano; Ferrara, Felicetto; De Simone, Mariacarla; Vietri, MariaTeresa; Cioffi, Michele; Sica, Vincenzo; Bresciani, Francesco; de Lera, Angel R.; Altucci, Lucia; Molinari, Anna Maria
  8. Structure, function and modulation of retinoic acid receptor beta, a tumor suppressor
    Alvarez, Susana; Germain, Pierre; Alvarez, Rosana; Rodriguez-Barrios, Fatima; Gronemeyer, Hinrich; De Lera, Angel R.
  9. Electrocyclic ring opening of cis-bicyclo[m.n.0]alkenes: the anti-Woodward-Hoffmann quest
    Lopez, Carlo Silva; Faza, Olalla Nieto; de Lera, Angel R.
  10. A density functional theory study of the stille cross-coupling via associative transmetalation. The role of ligands and coordinating solvents
    Alvarez, Rosana; Faza, Olalla Nieto; de Lera, Angel R.; Cardenas, Diego J.
  11. Pseudopericyclic design drives antara-antara [1,5] methylene sigmatropic shifts from a stepwise to a concerted mechanism
    Lopez, Carlos Silva; Faza, Olalla Nieto; Souto, Jose A.; Alvarez, Rosana; De Lera, Angel R.
  12. Bimetallic Intermediates in the Formation of Nucleophilic Allenylzincs from Allenylpalladiums: A DFT Study
    Alvarez, Rosana; De Lera, Angel R.; Aurrecoechea, Jose M.; Durana, Aritz
  13. Bispyridinium Dienes: Histone Deacetylase Inhibitors with Selective Activities
    Perez-Balado, Carlos; Nebbioso, Angela; Rodriguez-Grana, Paula; Minichiello, Annunziata; Miceli, Marco; Altucci, Lucia; de Lera, Angel R.
  14. Cyclopent-2-en-1-one derivatives as PPAR modulators, their preparation, pharmaceutical and cosmetic compositions, and uses thereof
    De Lera, Angel Rodriguez; Otero Cabredo, Maria Paz
  15. Sulfoxide-Induced Stereoselection in [1,5]-Sigmatropic Hydrogen Shifts of Vinylallenes. A Computational Study
    Faza, Olalla Nieto; Lopez, Carlos Silva; de Lera, Angel R.
  16. Total synthesis of peridinin and related C37-norcarotenoid butenolides
    Vaz, Belen; Dominguez, Marta; Alvarez, Rosana; de Lera, Angel R.
  17. Preparation of cyclopent-2-en-1-one derivatives as PPAR modulators and their use in cosmetic and pharmaceutical compositions
    De Lera, Angel Rodriguez; Otero, Cabredo Maria Paz

  18. Specificity of Zebrafish Retinol Saturase: Formation of All-trans-13,14-dihydroretinol and All-trans-7,8-dihydroretinol
    Moise, Alexander R.; Isken, Andrea; Dominguez, Marta; De Lera, Angel R.; Von Lintig, Johannes; Palczewski, Krzysztof

2006

  1. International union of pharmacology. LXIII. Retinoid X receptors
    Germain, Pierre; Chambon, Pierre; Eichele, Gregor; Evans, Ronald M.; Lazar, Mitchell A.; Leid, Mark; De Lera, Angel R.; Lotan, Reuben; Mangelsdorf, David J.; Gronemeyer, Hinrich
  2. International union of pharmacology. LX. Retinoic acid receptors
    Germain, Pierre; Chambon, Pierre; Eichele, Gregor; Evans, Ronald M.; Lazar, Mitchell A.; Leid, Mark; De Lera, Angel R.; Lotan, Reuben; Mangelsdorf, David J.; Gronemeyer, Hinrich
  3. Insights into the mechanism of the site-selective sequential palladium-catalyzed cross-coupling reactions of dibromothiophenes/dibromothiazoles and arylboronic acids. Synthesis of PPARb /d agonists
    Pereira, Raquel; Furst, Audrey; Iglesias, Beatriz; Germain, Pierre; Gronemeyer, Hinrich; de Lera, Angel R.
  4. The role of the 11-cis-retinal ring methyl substituents in visual pigment formation
    Dominguez, Marta; Alvarez, Rosana; Perez, Martin; Palczewski, Krzysztof; de Lera, Angel R.
  5. A methyl group at C7 of 11-cis-retinal allows chromophore formation but affects rhodopsin activation
    Bosch, Laia; Cordomi, Arnau; Dominguez, Marta; Toledo, Darwin; Morillo, Margarita; Perez, Juan J.; Alvarez, Rosana; de Lera, Angel R.; Garriga, Pere
  6. Activity of alcohol dehydrogenase with 11-cis-retinoids and distribution of ADH4 in ocular tissues
    Porte, Sergio; Martras, Silvia; Martinez, Susana E.; Alvarez, Rosana; Gallego, Oriol; Dominguez, Marta; Duester, Gregg; de Lera, Angel R.; Farres, Jaume; Pares, Xavier
  7. The Stille Reaction in the Synthesis of the C37-Norcarotenoid Butenolide Pyrrhoxanthin. Scope and Limitations
    Vaz, Belen; Dominguez, Marta; Alvarez, Rosana; de Lera, Angel R.
  8. Cycloisomerization of Activated (2E,4Z)-Heptatrienoate and Its Relevance to Crispatene (Bio)synthesis. A Case of Concerted and Stepwise Uncertainty
    Lopez, Carlos Silva; Faza, Olalla Nieto; Alvarez, Rosana; de Lera, Angel R.
  9. Computational Study and Analysis of the Kinetic Isotope Effects of the Rearrangement of cis-Bicyclo[4.2.0]oct-7-ene to cis,cis-Cycloocta-1,3-diene
    Silva Lopez, Carlos; Nieto Faza, Olalla; De Lera, Angel R.
  10. Natural and synthetic retinoids: structural bases and biological effects of potential clinical relevance for the prevention and treatment of infection-driven tumors
    Dolcetti, Riccardo; Di Luca, Dario; de Lera, Angel R.
  11. Mechanism of the Gold(I)-Catalyzed Rautenstrauch Rearrangement: A Center-to-Helix-to-Center Chirality Transfer
    Nieto Faza, Olalla; Silva Lopez, Carlos; Alvarez, Rosana; De Lera, Angel R.
  12. Computation of vertical excitation energies of retinal and analogs: Scope and limitations
    Lopez, Carlos Silva; Faza, Olalla Nieto; Estevez, Susana Lopez; De Lera, Angel R.
  13. Synthesis of enantiopure C3- and C4-hydroxyretinals and their enzymatic reduction by ADH8 from Xenopus laevis
    Dominguez, Marta; Alvarez, Rosana; Borras, Emma; Farres, Jaume; Pares, Xavier; De Lera, Angel R.
  14. Computational Characterization of a Complete Palladium-Catalyzed Cross-Coupling Process: The Associative Transmetalation in the Stille Reaction
    Alvarez, Rosana; Nieto Faza, Olalla; Silva Lopez, Carlos; de Lera, Angel R
  15. Synthesis of the PPARβ/δ-selective agonist GW501516 and C4-thiazole-substituted analogs
    Pereira, Raquel; Gaudon, Claudine; Iglesias, Beatriz; Germain, Pierre; Gronemeyer, Hinrich; de Lera, Angel R.

2005

  1. Mechanistic subtleties in the cyclopentannelation of allenolate allyl carbamates: the origin of the center-to-center chirality transfer
    Olalla Nieto, Carlos Silva, Rosana Alvarez and Angel R. de Lera
  2. Synthesis of N-heteroaryl Retinoids and Their Artificial Bacteriorhodopsins
    Susana López, Virginia Rodríguez, Javier Montenegro, Carlos Saá Rosana Álvarez, Carlos Silva, Angel R. de Lera, Rosana Simón, Tzvetana Lazarova and Esteve Padrós
  3. Ligand Recognition by RAR and RXR Receptors: Binding and Selectivity
    Fredy Sussman and Angel R. de Lera
  4. 2-Alkylidenesulfol-3-enes by (Regio and) Stereoselective Cheletropic Addition of SO2 to (Di)vinylallenes
    José A. Souto, Carlos Silva, Olalla Nieto Rosana Alvarez and Angel R. de Lera
  5. Simple Diastereoselectivity of the BF3·OEt2-Catalyzed Vinylogous Mukaiyama Aldol Reaction of 2-(Trimethylsiloxy)furans with Aldehydes
    Carlos Silva, Rosana Alvarez, Belén Vaz, Olalla Nieto and Angel R. de Lera
  6. Design and Synthesis of RXR Modulators
    Angel R. de Lera
  7. 14-Fluoro-Bacteriorhodopsin Gelation Films for Dynamic Holography Recording
    Elena Korchemskaya, Nicolai Burykin, Angel R. de Lera, Rosana Alvarez, Sergey Pirutin and Anna B. Druzhko
  8. Tumor-selective action of HDAC Inhibitors involves TRAIL induction in acute myeloid leukemia cells
    Angela Nebossio, Nicole Clarke, Paola Bontempo, Emilie Volz, Rosana Alvarez, Ettore M. Schiavone, Alexssandro Weisz, Francesco Bresciani, Angel R. de Lera, Hinrich Gronemeyer and Lucia Altucci
  9. Effect of Dehydration on Photoinduced Transformation in Gelatin Films Made of WT and D96N 14-Fluoro-bacteriorhodopsin
    Anna B. Druzhko, Sergey K. Pirutin, Angel R. de Lera, Rosana Alvarez and Howard, H. Weetall
  10. The Stille Reaction in the Synthesis of Carotenoid Butenolides: Synthesis of 6'-epi-Peridinin
    Belén Vaz, Rosana Alvarez, Reinhard Brückner and Angel R. de Lera
  11. γ-Allenyl Allyl Benzothiazole Sulfonyl Anions Undergo cis-Selective (Sylvestre) Julia Olefinations
    Belén Vaz, José A. Souto, Rosana Alvarez and Angel R. de Lera
  12. Characterization of the Interaction between Retinoic Acid Receptor/Retinoid X Receptor (RAR/RXR) Heterodimers and Transcriptional Coactivators through Structural and Fluorescence Anisotropy Studies
    Vivian Pogenberg, Jean-François Guichou, Valie Vivat-Hannah, Sabrina Kammerer, Efrén Pérez, Pierre Germain, Angel R. de Lera, Hinrich Gronemeyer, Catherine A. Royer and William Bourguet
  13. Ellipticity: A Convenient Tool to Characterize Electrocyclic Reactions
    Carlos Silva, Olalla Nieto, Fernando P. Cossío, Darrin M. York and Angel R. de Lera
  14. Pseudorotation Barriers of Biological Oxyphosphoranes: A Challenge for Simulations of Ribozyme Catalysis
    Carlos Silva, Olalla Nieto, Darrin M. York and Angel R. de Lera

2004

  1. The Specicifity of Alcohol Dehydrogenase With cis-Retinoids
    Silvia Martras, Rosana Alvarez, Susana E. Martínez, Dámaso Torres, Oriol Gallego, Gregg Duester, Jaume Farrés, Angel R. de Lera and Xavier Parés
  2. 14-Fluorobacteriorhodopsin gelatin films: performance at different relative humidities
    A. B. Druzhko, S. K. Pirutin, A. R. de Lera, R. Alvarez, S. Alvarez and M. Domínguez
  3. Enantioselective Synthesis of all of the Stereoisomers of (E)-13,14-Dihydroxyretinol (DHR)
    Susana Alvarez, Rosana Alvarez and Angel R. de Lera
  4. Conrotatory Ring Opening Reactions of Cyclopropyl Anions in Monocyclic and Tricyclic Systems
    Olalla Nieto, Carlos Silva, Rosana Alvarez and Angel R. de Lera
  5. The Woodward-Hoffmann-DePuy rule revisited
    Olalla Nieto, Carlos Silva, Rosana Alvarez and Angel R. de Lera
  6. Pseudorotation of natural and chemically modified biological phosphoranes: implications for RNA catalysis
    Carlos Silva, Olalla Nieto, Brent A. Gregersen, X. López, Angel R. de Lera and D. M. York
  7. Theoretical Study of the Vinyl Allene Oxide to Cyclopent-2-en-1-one Rearrangement: Mechanism, Torquoselectivity and Solvent Effects
    Carlos Silva, Olalla Nieto, Darrin M. York and Angel R. de Lera
  8. Theoretical Study of the Electrocyclic Ring Closure of Hydroxypentadienyl Cations
    Olalla Nieto, Carlos Silva, Rosana Alvarez and Angel R. de Lera
  9. Rational design of RAR selective agonists revealed by RAR-β crystal structure
    Pierre Gemain, Sabrina Kammerer, Efrén Pérez, Carole Peluso-Iltis, David Tortolani, F. Cristopher Zusi, John Starrett, Philippe Lapointe, Jean-Paull Daris, Anne Marinier, Angel R. de Lera, Natasha Rochel, Hinrich Gronemeyer
  10. Kinetics of human alcohol dehydrogenase with ring-oxidized retinoids: effect of Tween 80
    Silvia Martras, Rosana Alvarez, Oriol Gallego, Marta Domínguez, Angel R. de Lera, Jaume Farrés and Xavier Parés
  11. 9-cis Retinoic Acid Analogues With Bulky Hydrophobic Rings: New RXR-Selective Agonists
    Rosana Alvarez, M. Jess Vega, Sabrina Kammerer, Aurèlie Rossin, Pierre Germain, Hinrich Gronemeyer and Angel R. de Lera
  12. Synthesis of Ring-oxidized Retinoids as Substrates of Mouse Class I Alcohol Dehydrogenase (ADH1)
    Marta Domínguez, Rosana Alvarez, Silvia Martras, Jaume Farré, Xavier Parés and Angel R. de Lera
  13. Solvolytic Ring Opening Reactions of Cyclopropyl Halides. An Assessment of the Woodward-Hoffmann-DePuy Rule
    Olalla Nieto, Carlos Silva, Rosana Alvarez and Angel R. de Lera

2003

  1. Recent Advances in the Synthesis of Retinoids
    Beatriz Domínguez, Rosana Alvarez and Angel R. de Lera
  2. 9Z- and 11Z-8-Methylretinals for Artificial Visual Pigment Studies. Stereoselective Synthesis, Structure and Binding Modeling
    Rosana Alvarez, Marta Domínguez, Yolanda Pazos, Fredy Sussman and Angel R. de Lera

2002

  1. Synthesis and Characterization of a New RXR Agonist Based on the 6-tert-Butyl-1,1-dimethylindanyl Structure
    Beatriz Domínguez, M. Jesús Vega, Fredy Sussman and Angel R. de Lera
  2. Stereoselective Synthesis of Annular 9-cis-Retinoids and Binding Characterization to the Retinoid X Receptor
    M. Paz Otero, Alicia Torrado, Yolanda Pazos, Fredy Sussman and Angel R. de Lera
  3. Synthesis of Symmetrical Carotenoids by a Two-fold Stille Coupling
    Belén Vaz, Rosana Alvarez and Angel R. de Lera
  4. Reply to: Electrocyclization of (Z)-1,2,4,6-Heptatetraene and Its Heterosubstituted Analogs: Pericyclic or Pseudopericyclic?
    Angel R. de Lera and Fernando P. Cossío
  5. Bleaching kinetics of artificial visual pigments with modifications near the ring/polyene chain connection
    Istvan Szundi, Angel R. de Lera, Yolanda Pazos, Rosana Alvarez, Marco Oliana, Mordechai Sheves, James W. Lewis and David S. Kliger

2001

  1. Photoinduced Transformation of 14-F-Bacteriorhodopsin Gelatin Films Based on Both Wild Type and D96N Mutants
    Anna B. Druzhko, V.Y. Shakhbazian, Rosana Alvarez, Angel R. de Lera and Howard H. Weetall
  2. An Expedient Stereocontrolled Synthesis of 7-cis-Retinoids
    Rosana Alvarez, Beatriz Domínguez and Angel R. de Lera
  3. On the Aromatic Character of Electrocyclic and Pseudopericyclic Reactions: Thermal Cyclization of (2Z)-Hexa-2,4,5-trienals and their Schiff Bases
    Angel R. de Lera, Rosana Alvarez, Begoña Lecea, Alicia Torrado and Fernando P. Cossío
  4. A General Synthesis of Alkylpyridines
    Beatriz Iglesias, Rosana Alvarez and Angel R. de Lera
  5. Regioselective palladium-catalyzed cross-coupling reactions in the synthesis of novel 2,3-disubstituted thiophene derivatives
    Raquel Pereira, Beatriz Iglesias and Angel R. de Lera
  6. Suzuki cross-coupling of meso-dibromoporphyrins for the synthesis of functionalized A2B2 porphyrins
    Belén Vaz, Rosana Alvarez, Mar Nieto, Antonio I. Paniello and Angel R. de Lera
  7. The Suzuki Coupling Reaction in the Stereocontrolled Synthesis of 9-cis-Retinoic Acid and Its Ring-Demethylated Analogues
    Yolanda Pazos, Beatriz Iglesias and Angel R. de Lera

2000

  1. A Pericyclic Cascade to the Stereocontrolled Synthesis of 9-cis-Retinoids
    Beatriz Iglesias, Alicia Torrado, and Angel R. de Lera
  2. Measurement of Proton Release and Uptake by Analogs of Bacteriorhodopsin
    Howard H. Weetall , Anna B. Druzhko, Angel R. de Lera, Rosana Alvarez and Baldwin Robertson
  3. Torquoselectivity in the Cationic Cyclopentannelation of (2Z)-Hexa-2,4,5-trienal Acetals
    Angel R. de Lera, Beatriz Iglesias, Susana López and Jesús Rodríguez
  4. Stereocontrolled Synthesis of 6-s-cis- and 6-s-trans-Locked 9Z-Retinoids by Hydroxyl-Accelerated Stille Coupling of (Z)-Tri-n-Butylstannylbut-2-en-1-ol and Bicyclic Dienyl Triflates
    Beatriz Domínguez, Yolanda Pazos and Angel R. de Lera
  5. Isomerization of all-trans-Retinol to cis-Retinols in Bovine Retinal Pigment Epithelial Cells: Dependence on the Specificity of Retinoid-Binding Proteins
    J. K. McBee, V. Kuksa, R. Alvarez, Angel R. de Lera, O. Prezhdo, F. Haeseleer, I. Sokal and K. Palczewski